TACC2 Antibody (H-8): sc-515342
- TACC2 Antibody (H-8) is a mouse monoclonal IgG1 κ TACC2 antibody provided at 200 µg/ml
- raised against amino acids 2294-2421 mapping near the C-terminus of TACC2 of human origin
- TACC2 Antibody (H-8) is recommended for detection of TACC2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TACC2 Antibody (H-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TACC2 Antibody (H-8) for WB applications. These reagents are now offered in bundles with TACC2 Antibody (H-8) (see ordering information below).
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TACC2 Antibody (H-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects TACC2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TACC2 (H-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TACC2 protein, part of the transforming acidic coiled-coil (TACC) family, plays a crucial role in cell cycle regulation and mitotic spindle assembly, which are essential processes for proper cell division and maintaining genomic stability. Dysregulation of TACC2 has been implicated in various cancers, highlighting TACC2′s importance in tumorigenesis. The TACC family, which includes TACC1, TACC2, and TACC3, is located in close proximity to fibroblast growth factor receptor genes, suggesting a potential interplay in signaling pathways that govern cell growth and differentiation. Understanding TACC2 function and interactions within the cellular environment can provide insights into TACC2′s role in cancer biology and therapeutic targets.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TACC2 Antibody (H-8) References:
- Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and Fibroblast Growth Factor Receptor 1 (FGFR1) as candidate breast cancer genes. | Ugolini, F., et al. 1999. Oncogene. 18: 1903-10. PMID: 10086345
- The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. | Still, IH., et al. 1999. Genomics. 58: 165-70. PMID: 10366448
- Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon. | Still, IH., et al. 1999. Oncogene. 18: 4032-8. PMID: 10435627
- D-TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo. | Gergely, F., et al. 2000. EMBO J. 19: 241-52. PMID: 10637228
- Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2. | Lauffart, B., et al. 2003. Genomics. 81: 192-201. PMID: 12620397
- The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer. | Schuendeln, MM., et al. 2004. Mol Cell Biol. 24: 6403-9. PMID: 15226440
- TTK kinase is essential for the centrosomal localization of TACC2. | Dou, Z., et al. 2004. FEBS Lett. 572: 51-6. PMID: 15304323
- Characterization of the region of the short arm of chromosome 8 amplified in breast carcinoma. | Dib, A., et al. 1995. Oncogene. 10: 995-1001. PMID: 7898940
- The expression and localization of fibroblast growth factor-1 (FGF-1) and FGF receptor-1 (FGFR-1) in human breast cancer. | Yoshimura, N., et al. 1998. Clin Immunol Immunopathol. 89: 28-34. PMID: 9756721
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TACC2 Antibody (H-8) | sc-515342 | 200 µg/ml | $316.00 | |||
TACC2 Antibody (H-8): m-IgG Fc BP-HRP Bundle | sc-531343 | 200 µg Ab; 10 µg BP | $354.00 | |||
TACC2 Antibody (H-8): m-IgGκ BP-HRP Bundle | sc-525008 | 200 µg Ab, 40 µg BP | $354.00 | |||
TACC2 Antibody (H-8): m-IgG1 BP-HRP Bundle | sc-544495 | 200 µg Ab; 20 µg BP | $354.00 | |||
TACC2 Antibody (H-8) AC | sc-515342 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TACC2 Antibody (H-8) HRP | sc-515342 HRP | 200 µg/ml | $316.00 | |||
TACC2 Antibody (H-8) FITC | sc-515342 FITC | 200 µg/ml | $330.00 | |||
TACC2 Antibody (H-8) PE | sc-515342 PE | 200 µg/ml | $343.00 | |||
TACC2 Antibody (H-8) Alexa Fluor® 488 | sc-515342 AF488 | 200 µg/ml | $357.00 | |||
TACC2 Antibody (H-8) Alexa Fluor® 546 | sc-515342 AF546 | 200 µg/ml | $357.00 | |||
TACC2 Antibody (H-8) Alexa Fluor® 594 | sc-515342 AF594 | 200 µg/ml | $357.00 | |||
TACC2 Antibody (H-8) Alexa Fluor® 647 | sc-515342 AF647 | 200 µg/ml | $357.00 | |||
TACC2 Antibody (H-8) Alexa Fluor® 680 | sc-515342 AF680 | 200 µg/ml | $357.00 | |||
TACC2 Antibody (H-8) Alexa Fluor® 790 | sc-515342 AF790 | 200 µg/ml | $357.00 |