TAB182 Antibody (G-5): sc-514490

TAB182 Antibody (G-5) is a mouse monoclonal IgG1 antibody that detects TAB182 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TAB182 is a critical protein that interacts with Tankyrase-1 and Tankyrase-2, both of which are poly(ADP-ribose) polymerases involved in various cellular processes, including telomere maintenance and vesicular trafficking. The interaction between TAB182 and Tankyrases facilitates the poly(ADP-ribosyl)ation of TAB182, a post-translational modification that can influence protein stability, localization, and function. This modification is essential for regulating cellular responses to stress and DNA damage, highlighting TAB182′s importance in maintaining genomic integrity and cellular homeostasis. TAB182 is expressed in multiple tissues, including the kidney, pancreas, heart, lung, liver, ovary, and to a lesser extent, the brain and peripheral blood leukocytes, and localizes to both the nucleus and cytoplasm, where TAB182 colocalizes with the cortical actin network. The structural features of TAB182, including N-terminal and C-terminal domains and the large internal acidic region, contribute to functional versatility and interaction capabilities, making TAB182 a vital component in various signaling pathways and cellular functions. Anti-TAB182 antibody (G-5) is an invaluable tool for researchers studying the roles of Tankyrase binding proteins in cellular processes and disease mechanisms.

The preferred TAB182 antibody is TAB182 Antibody (D-5): sc-514517.