TAB182 Antibody (D-5): sc-514517
- TAB182 Antibody (D-5) is a mouse monoclonal IgG2b κ TAB182 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1151-1176 within an internal region of TAB182 of human origin
- TAB182 Antibody (D-5) is recommended for detection of TAB182 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TAB182 Antibody (D-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TAB182 Antibody (D-5) for WB applications. These reagents are now offered in bundles with TAB182 Antibody (D-5) (see ordering information below).
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TAB182 Antibody (D-5) is a mouse monoclonal IgG2b kappa light chain antibody that detects TAB182 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TAB182 (D-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TAB182 acts as a binding partner for Tankyrase-1 and Tankyrase-2, which are poly(ADP-ribose) polymerases involved in telomere maintenance and vesicular trafficking. This interaction facilitates TAB182 poly(ADP-ribosyl)ation, a post-translational modification that can influence protein stability and function. TAB182 is expressed in various tissues, including kidney, pancreas, heart, lung, liver, ovary, and to a lesser extent, brain and peripheral blood leukocytes. TAB182 localizes in both nucleus and cytoplasm, where TAB182 colocalizes with cortical actin network, highlighting a potential role in cytoskeletal organization and cellular signaling. TAB182 structure includes two basic regions at N-terminal and C-terminal domains, along with a large internal acidic region, and C-terminal domain features two potential nuclear localization signals, which may be important for cellular compartmentalization and signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TAB182 Antibody (D-5) References:
- Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. | Cook, BD., et al. 2002. Mol Cell Biol. 22: 332-42. PMID: 11739745
- The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182). | Seimiya, H. and Smith, S. 2002. J Biol Chem. 277: 14116-26. PMID: 11854288
- Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner. | Sbodio, JI. and Chi, NW. 2002. J Biol Chem. 277: 31887-92. PMID: 12080061
- Soluble tankyrase located in cytosol of human embryonic kidney cell line 293. | Kuimov, AN. and Terekhov, SM. 2003. Biochemistry (Mosc). 68: 260-8. PMID: 12733967
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TAB182 Antibody (D-5) | sc-514517 | 200 µg/ml | $316.00 | |||
TAB182 Antibody (D-5): m-IgGκ BP-HRP Bundle | sc-524752 | 200 µg Ab, 40 µg BP | $354.00 | |||
TAB182 Antibody (D-5): m-IgG2b BP-HRP Bundle | sc-549177 | 200 µg Ab; 10 µg BP | $354.00 | |||
TAB182 Antibody (D-5) AC | sc-514517 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TAB182 Antibody (D-5) HRP | sc-514517 HRP | 200 µg/ml | $316.00 | |||
TAB182 Antibody (D-5) FITC | sc-514517 FITC | 200 µg/ml | $330.00 | |||
TAB182 Antibody (D-5) PE | sc-514517 PE | 200 µg/ml | $343.00 | |||
TAB182 Antibody (D-5) Alexa Fluor® 488 | sc-514517 AF488 | 200 µg/ml | $357.00 | |||
TAB182 Antibody (D-5) Alexa Fluor® 546 | sc-514517 AF546 | 200 µg/ml | $357.00 | |||
TAB182 Antibody (D-5) Alexa Fluor® 594 | sc-514517 AF594 | 200 µg/ml | $357.00 | |||
TAB182 Antibody (D-5) Alexa Fluor® 647 | sc-514517 AF647 | 200 µg/ml | $357.00 | |||
TAB182 Antibody (D-5) Alexa Fluor® 680 | sc-514517 AF680 | 200 µg/ml | $357.00 | |||
TAB182 Antibody (D-5) Alexa Fluor® 790 | sc-514517 AF790 | 200 µg/ml | $357.00 | |||
TAB182 (D-5) Neutralizing Peptide | sc-514517 P | 100 µg/0.5 ml | $68.00 |