Syntaxin 7 Antibody (A-1): sc-514017
- Syntaxin 7 Antibody (A-1) is a mouse monoclonal IgG2b κ Syntaxin 7 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 88-160 mapping within an internal region of Syntaxin 7 of human origin
- Syntaxin 7 Antibody (A-1) is recommended for detection of Syntaxin 7 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Syntaxin 7 Antibody (A-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Syntaxin 7 Antibody (A-1) for WB and IHC(P) applications. These reagents are now offered in bundles with Syntaxin 7 Antibody (A-1) (see ordering information below).
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Syntaxin 7 Antibody (A-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects Syntaxin 7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Syntaxin 7 (A-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Syntaxin 7 plays a crucial role in the fusion of late endosomes, which is vital for maintaining cellular homeostasis and facilitating the transport of proteins and lipids within the cell. Located primarily in late endosomal compartments, Syntaxin 7 interacts with other SNARE proteins, such as Syntaxin 8, vti1b, and VAMP-8, to form a SNARE complex that drives the fusion of vesicles with target membranes. This process is essential for proper functioning of cellular trafficking pathways, and any disruption can lead to various diseases, including neurodegenerative disorders. Syntaxin 7′s ability to bind α-SNAP in vitro further highlights its importance in the assembly of the SNARE complex, which is necessary for energy-efficient fusion of lipid bilayers. Notably, Syntaxin 7 expression increases in B16 melanoma cells during melanogenesis, suggesting involvement in the regulation of this process through interactions with VAMP7 or VAMP8.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Syntaxin 7 Antibody (A-1) References:
- A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function. | Antonin, W., et al. 2000. EMBO J. 19: 6453-64. PMID: 11101518
- Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells. | Wade, N., et al. 2001. J Biol Chem. 276: 19820-7. PMID: 11278762
- The syntaxin family of vesicular transport receptors. | Bennett, MK., et al. 1993. Cell. 74: 863-73. PMID: 7690687
- Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine. | Edelmann, L., et al. 1995. EMBO J. 14: 224-31. PMID: 7835333
- Exocytosis relating proteins in the nervous system. | Yamaguchi, K. and Akagawa, K. 1994. Neurosci Res. 20: 289-92. PMID: 7870381
- Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly. | Hayashi, T., et al. 1994. EMBO J. 13: 5051-61. PMID: 7957071
- A role for synaptotagmin (p65) in regulated exocytosis. | Elferink, LA., et al. 1993. Cell. 72: 153-9. PMID: 8422678
- Stimulation of NSF ATPase activity by alpha-SNAP is required for SNARE complex disassembly and exocytosis. | Barnard, RJ., et al. 1997. J Cell Biol. 139: 875-83. PMID: 9362506
- Structural organization of the synaptic exocytosis core complex. | Lin, RC. and Scheller, RH. 1997. Neuron. 19: 1087-94. PMID: 9390521
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Syntaxin 7 Antibody (A-1) | sc-514017 | 200 µg/ml | $316.00 | |||
Syntaxin 7 Antibody (A-1): m-IgG Fc BP-HRP Bundle | sc-531003 | 200 µg Ab; 10 µg BP | $354.00 | |||
Syntaxin 7 Antibody (A-1): m-IgGκ BP-HRP Bundle | sc-524574 | 200 µg Ab, 40 µg BP | $354.00 | |||
Syntaxin 7 Antibody (A-1): m-IgG2b BP-HRP Bundle | sc-550248 | 200 µg Ab; 10 µg BP | $354.00 | |||
Syntaxin 7 Antibody (A-1) AC | sc-514017 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Syntaxin 7 Antibody (A-1) HRP | sc-514017 HRP | 200 µg/ml | $316.00 | |||
Syntaxin 7 Antibody (A-1) FITC | sc-514017 FITC | 200 µg/ml | $330.00 | |||
Syntaxin 7 Antibody (A-1) PE | sc-514017 PE | 200 µg/ml | $343.00 | |||
Syntaxin 7 Antibody (A-1) Alexa Fluor® 488 | sc-514017 AF488 | 200 µg/ml | $357.00 | |||
Syntaxin 7 Antibody (A-1) Alexa Fluor® 546 | sc-514017 AF546 | 200 µg/ml | $357.00 | |||
Syntaxin 7 Antibody (A-1) Alexa Fluor® 594 | sc-514017 AF594 | 200 µg/ml | $357.00 | |||
Syntaxin 7 Antibody (A-1) Alexa Fluor® 647 | sc-514017 AF647 | 200 µg/ml | $357.00 | |||
Syntaxin 7 Antibody (A-1) Alexa Fluor® 680 | sc-514017 AF680 | 200 µg/ml | $357.00 | |||
Syntaxin 7 Antibody (A-1) Alexa Fluor® 790 | sc-514017 AF790 | 200 µg/ml | $357.00 |