Synaptotagmin XI Antibody (H-7): sc-515632

Synaptotagmin XI Antibody (H-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects Synaptotagmin XI in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Synaptotagmin XI antibody (H-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Synaptotagmin XI, also known as SYT11, is a 431 amino acid protein that plays a crucial role in the regulation of neurotransmitter release, acting as a calcium sensor during vesicular trafficking. Synaptotagmin XI is primarily localized to the membrane and exhibits ubiquitous expression, with highest levels found in brain and lung. Unlike other synaptotagmin family members, Synaptotagmin XI functions independently of calcium due to a specific point mutation in one C2 domain, which alters calcium-binding capacity. This unique characteristic influences interactions with other proteins, such as ubiquitin-E3-ligase Parkin, which associates with polyubiquitination and degradation of Synaptotagmin XI via proteasome complex. Synaptotagmin XI involvement in these pathways highlights significance in neurological health, as gene defects have been linked to various disorders, including schizophrenia and Parkinson′s disease.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Synaptotagmin XI Antibody (H-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Synaptotagmin XI Antibody (H-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Synaptotagmin XI Antibody (H-7) Specifications

Alternate Product Name: Synaptotagmin XI

Product Clone Name: H-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-20

Epitope Target: Synaptotagmin XI

Epitope Species: human

Product Reactivity/Detection: Synaptotagmin XI

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Synaptotagmin XI Antibody (H-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred Synaptotagmin XI antibody is Synaptotagmin XI Antibody (D-5): sc-365991.