Synaptojanin 2 Antibody (E-1): sc-390354
- Synaptojanin 2 Antibody (E-1) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1118-1135 at the C-terminus of Synaptojanin 2 of mouse origin
- recommended for detection of all mouse Synaptojanin 2 isoforms (α-Ω) and rat and human Synaptojanin 2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and bovine and porcine
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Synaptojanin 2 Antibody (E-1) for WB and IHC(P) applications. These reagents are now offered in bundles with Synaptojanin 2 Antibody (E-1) (see ordering information below).
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Synaptojanin 2 Antibody (E-1) is a mouse monoclonal IgG2b antibody that detects synaptojanin 2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Synaptojanin 2 plays a crucial role in the endocytosis of synaptic vesicles, which is essential for neurotransmitter release and synaptic transmission, thereby influencing neuronal communication and plasticity. Anti-synaptojanin 2 antibody (E-1) targets proteins primarily located in the presynaptic terminals of neurons, where synaptojanin 2 is involved in recycling synaptic vesicles, a process vital for maintaining synaptic function and preventing neurotransmitter depletion during sustained activity. Multiple isoforms and splice variants of synaptojanin 2, particularly the brain-specific isoform, highlight specialized functions in different tissues and developmental stages, making synaptojanin 2 a significant focus for research into synaptic dynamics and neurodegenerative diseases. Synaptojanin 2 monoclonal antibody (E-1) is an invaluable tool for studying these processes, providing insights into molecular mechanisms underlying synaptic function and potential therapeutic targets for neurological disorders.
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Synaptojanin 2 Antibody (E-1) References:
- Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein. | Nemoto, Y. and De Camilli, P. 1999. EMBO J. 18: 2991-3006. PMID: 10357812
- Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis. | Malecz, N., et al. 2000. Curr Biol. 10: 1383-6. PMID: 11084340
- Identification and characterization of a synaptojanin 2 splice isoform predominantly expressed in nerve terminals. | Nemoto, Y., et al. 2001. J Biol Chem. 276: 41133-42. PMID: 11498538
- Synaptojanin 2 is recognized by HLA class II-restricted hairy cell leukemia-specific T cells. | Spaenij-Dekking, EH., et al. 2003. Leukemia. 17: 2467-73. PMID: 14562116
- Role of synaptojanin 2 in glioma cell migration and invasion. | Chuang, YY., et al. 2004. Cancer Res. 64: 8271-5. PMID: 15548694
- A mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart. | Manji, SS., et al. 2011. PLoS One. 6: e17607. PMID: 21423608
- Regulation of synaptojanin 2 5'-phosphatase activity by Src. | Chuang, Y., et al. 2012. Cell Adh Migr. 6: 518-25. PMID: 23076136
- Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis. | Adam, MG., et al. 2013. Circ Res. 113: 1206-18. PMID: 24025447
- Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer. | Ben-Chetrit, N., et al. 2015. Sci Signal. 8: ra7. PMID: 25605973
- High-resolution visualization and assessment of basal and OXPHOS-induced mitophagy in H9c2 cardiomyoblasts. | Godtliebsen, G., et al. 2023. Autophagy. 19: 2769-2788. PMID: 37405374
- Control of the signaling role of PtdIns(4)P at the plasma membrane through H2O2-dependent inactivation of synaptojanin 2 during endocytosis. | Jo, SI., et al. 2024. Redox Biol. 71: 103097. PMID: 38442648
- Synaptojanin 2, a novel synaptojanin isoform with a distinct targeting domain and expression pattern. | Nemoto, Y., et al. 1997. J Biol Chem. 272: 30817-21. PMID: 9388224
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Synaptojanin 2 Antibody (E-1) | sc-390354 | 200 µg/ml | $322.00 | |||
Synaptojanin 2 Antibody (E-1): m-IgG Fc BP-HRP Bundle | sc-538081 | 200 µg Ab; 10 µg BP | $361.00 | |||
Synaptojanin 2 Antibody (E-1): m-IgGκ BP-HRP Bundle | sc-535616 | 200 µg Ab; 40 µg BP | $361.00 | |||
Synaptojanin 2 Antibody (E-1): m-IgG2b BP-HRP Bundle | sc-549917 | 200 µg Ab; 10 µg BP | $361.00 | |||
Synaptojanin 2 (E-1) Neutralizing Peptide | sc-390354 P | 100 µg/0.5 ml | $69.00 |