Syk Antibody (G-2): sc-28337
- Syk Antibody (G-2) is a mouse monoclonal IgG2a κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 257-352 of Syk of human origin
- recommended for detection of Syk of human origin by WB, IP, IF, IHC(P) and ELISA
- See Syk (4D10): sc-1240 for Syk antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Syk Antibody (G-2) for WB and IHC(P) applications. These reagents are now offered in bundles with Syk Antibody (G-2) (see ordering information below).
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SEE ALSO...
Syk Antibody (G-2) is a mouse monoclonal IgG2a antibody that detects Syk in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Syk, or spleen tyrosine kinase, is a 635 amino acid protein characterized by one protein kinase domain and two SH2 domains, playing a crucial role as a positive effector in B cell antigen receptor (CD79)-stimulated responses. Syk is essential for coupling CD79 with calcium ion movement through two phospho-regulated pathways, which are vital for various cellular processes. Specifically, when unphosphorylated, Syk directs calcium ions through a phosphoinositide 3-kinase-dependent pathway, while phosphorylation at Tyr 348 and Tyr 352 shifts the pathway to a phospholipase C γ-dependent route. Syk regulation of calcium movement influences critical cellular responses such as differentiation, phagocytosis, proliferation, and B cell development. Additionally, Syk expression shows notable upregulation in T cell lymphoma, indicating potential involvement in tumorigenesis. Alternative splicing events produce two Syk isoforms, designated short and long, adding another layer of complexity to functional diversity. anti-Syk antibody (G-2) serves as an invaluable tool for researchers investigating immune responses and cancer biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Syk Antibody (G-2) | sc-28337 | 200 µg/ml | $322.00 | |||
Syk Antibody (G-2): m-IgG Fc BP-HRP Bundle | sc-536714 | 200 µg Ab; 10 µg BP | $361.00 | |||
Syk Antibody (G-2): m-IgGκ BP-HRP Bundle | sc-533874 | 200 µg Ab; 40 µg BP | $361.00 | |||
Syk Antibody (G-2): m-IgG2a BP-HRP Bundle | sc-547856 | 200 µg Ab; 10 µg BP | $361.00 |