SV40 T Ag Antibody (C-1): sc-55461

SV40 T Ag Antibody (C-1) is a mouse monoclonal IgG2a antibody that detects SV40 T antigen in SV40 by applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SV40 T antigen plays a crucial role in the viral life cycle and is essential for the transformation of host cells, as SV40 T antigen interacts with key cellular proteins that regulate cell growth and division. Notably, SV40 T antigen binds to the retinoblastoma (Rb) protein, specifically targeting the "pocket" domain, which is also the binding site for the E2F transcription factor. This interaction leads to the inactivation of Rb, disrupting Rb′s ability to regulate the cell cycle and promoting uncontrolled cell proliferation. SV40 T antigen′s ability to modulate these critical pathways highlights SV40 T antigen′s importance in understanding viral oncogenesis and the mechanisms of malignant transformation. With specificity for SV40 and versatility in various applications, anti-SV40 T antigen antibody (C-1) serves as an invaluable tool for researchers studying the molecular interactions and pathways involved in SV40-induced cellular transformation.

The preferred SV40 T Ag antibody is SV40 T Ag Antibody (Pab 101): sc-147.