SV2B Antibody (C-3): sc-166004

SV2B Antibody (C-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects SV2B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SV2B Antibody (C-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SV2B protein, also known as Synaptic Vesicle Protein 2B Homolog, plays a crucial role in synaptic transmission by regulating neurotransmitter release at synapses, which is vital for proper neuronal communication and overall brain function. SV2B protein is predominantly localized to synaptic vesicles in specific regions of the brain, such as the hippocampus and cortex, where SV2B protein is involved in modulating calcium ion levels during synaptic activity. This selective expression pattern highlights SV2B protein′s importance in facilitating neurotransmitter release in a subset of synapses, thereby contributing to the fine-tuning of synaptic responses and plasticity. The functional redundancy between SV2A and SV2B underscores their collective necessity for maintaining normal brain function, making anti-SV2B antibody (C-3) an essential tool for researchers studying synaptic mechanisms and neurobiology.

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SV2B Antibody (C-3) References:

1. SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release.  |  Janz, R., et al. 1999. Neuron. 24: 1003-16. PMID: 10624962
2. SV2C is a synaptic vesicle protein with an unusually restricted localization: anatomy of a synaptic vesicle protein family.  |  Janz, R. and Südhof, TC. 1999. Neuroscience. 94: 1279-90. PMID: 10625067
3. SV2B regulates synaptotagmin 1 by direct interaction.  |  Lazzell, DR., et al. 2004. J Biol Chem. 279: 52124-31. PMID: 15466855
4. Loss of the Synaptic Vesicle Protein SV2B results in reduced neurotransmission and altered synaptic vesicle protein expression in the retina.  |  Morgans, CW., et al. 2009. PLoS One. 4: e5230. PMID: 19381277
5. Altered balance between excitatory and inhibitory inputs onto CA1 pyramidal neurons from SV2A-deficient but not SV2B-deficient mice.  |  Venkatesan, K., et al. 2012. J Neurosci Res. 90: 2317-27. PMID: 22847229
6. Lack of synaptic vesicle protein SV2B protects against amyloid-β₂₅₋₃₅-induced oxidative stress, cholinergic deficit and cognitive impairment in mice.  |  Detrait, E., et al. 2014. Behav Brain Res. 271: 277-85. PMID: 24937053
7. SV2B is essential for the integrity of the glomerular filtration barrier.  |  Fukusumi, Y., et al. 2015. Lab Invest. 95: 534-45. PMID: 25730372
8. Identification of a transmembrane glycoprotein specific for secretory vesicles of neural and endocrine cells.  |  Buckley, K. and Kelly, RB. 1985. J Cell Biol. 100: 1284-94. PMID: 2579958
9. Endocrine secretory granules and neuronal synaptic vesicles have three integral membrane proteins in common.  |  Lowe, AW., et al. 1988. J Cell Biol. 106: 51-9. PMID: 3276713
10. SV2B/miR-34a/miR-128 axis as prognostic biomarker in glioblastoma multiforme.  |  Mustafov, D., et al. 2024. Sci Rep. 14: 6647. PMID: 38503772
11. Functional genomics screens reveal a role for TBC1D24 and SV2B in antibody-dependent enhancement of dengue virus infection.  |  Belmont, L., et al. 2024. J Virol. 98: e0158224. PMID: 39377586
12. Brain contains two forms of synaptic vesicle protein 2.  |  Bajjalieh, SM., et al. 1993. Proc Natl Acad Sci U S A. 90: 2150-4. PMID: 7681585

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SV2B Antibody (C-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SV2B Antibody (C-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SV2B Antibody (C-3) Specifications

Alternate Product Name: Synaptic Vesicle Glycoprotein 2B

Product Clone Name: C-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-126

Epitope Target: SV2B

Epitope Species: rat

Product Reactivity/Detection: SV2B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SV2B Antibody (C-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred SV2A antibody is SV2A Antibody (E-8): sc-376234.