survivin Antibody (8E2): sc-47750
- survivin Antibody (8E2) is a mouse monoclonal IgG1 κ, cited in 8 publications, provided at 200 µg/ml
- raised against full length human survivin
- recommended for detection of survivin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See survivin (D-8): sc-17779 for survivin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for survivin Antibody (8E2) for WB and IHC(P) applications. These reagents are now offered in bundles with survivin Antibody (8E2) (see ordering information below).
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Survivin Antibody (8E2) is a mouse monoclonal IgG1 antibody that detects survivin in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Survivin plays a crucial role in regulating cell division and inhibiting apoptosis, making survivin a significant factor in cancer biology, as survivin overexpression is often associated with tumor progression and resistance to chemotherapy. Survivin is primarily located in the cytoplasm and nucleus of dividing cells, where survivin associates with the mitotic spindle during cell division, ensuring proper chromosomal segregation. Survivin localization is vital because survivin not only contributes to the prevention of apoptosis but also plays a role in maintaining the integrity of the mitotic process, thereby influencing cell proliferation. Additionally, survivin interaction with microtubules is essential for function, as disruptions in this association can lead to increased caspase-3 activity and subsequent apoptosis, highlighting survivin importance in cancer therapy and potential as a therapeutic target. Anti-survivin antibody (8E2) is an invaluable tool for researchers studying the mechanisms of cell cycle regulation and apoptosis in various biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
survivin Antibody (8E2) | sc-47750 | 200 µg/ml | $316.00 | |||
survivin Antibody (8E2): m-IgG Fc BP-HRP Bundle | sc-536807 | 200 µg Ab; 10 µg BP | $354.00 | |||
survivin Antibody (8E2): m-IgGκ BP-HRP Bundle | sc-533972 | 200 µg Ab; 40 µg BP | $354.00 | |||
survivin Antibody (8E2): m-IgG1 BP-HRP Bundle | sc-544830 | 200 µg Ab; 20 µg BP | $354.00 |