SUG1 Antibody (H-7): sc-390631

SUG1 Antibody (H-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects SUG1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SUG1 (H-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SUG1 protein, also known as PSMC5 (Proteasome 26S subunit ATPase 5), plays a crucial role as an ATPase subunit within the 26S proteasome complex, which is essential for the regulated degradation of ubiquitinated proteins. SUG1 protein is localized in both the cytoplasm and nucleus, where SUG1 is part of the 19S regulatory particle that confers substrate specificity and facilitates the ATP-dependent degradation of proteins, particularly those misfolded or damaged in the endoplasmic reticulum. SUG1 protein′s importance extends to involvement in the assembly of the 26S proteasome, which has been shown to be dependent on phosphorylation by specific protein kinases. Additionally, SUG1 protein interacts with key transcription factors such as the retinoid X receptor and thyroid hormone receptor, indicating a potential role in the regulation of gene expression.

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SUG1 Antibody (H-7) References:

1. Expression of nuclear receptor interacting proteins TIF-1, SUG-1, receptor interacting protein 140, and corepressor SMRT in tamoxifen-resistant breast cancer.  |  Chan, CM., et al. 1999. Clin Cancer Res. 5: 3460-7. PMID: 10589759
2. Human Sug1/p45 is involved in the proteasome-dependent degradation of Sp1.  |  Su, K., et al. 2000. Biochem J. 348 Pt 2: 281-9. PMID: 10816420
3. The Gal4 activation domain binds Sug2 protein, a proteasome component, in vivo and in vitro.  |  Chang, C., et al. 2001. J Biol Chem. 276: 30956-63. PMID: 11418596
4. Phosphorylation by p38MAPK and recruitment of SUG-1 are required for RA-induced RAR gamma degradation and transactivation.  |  Giannì, M., et al. 2002. EMBO J. 21: 3760-9. PMID: 12110588
5. Inhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisons.  |  Yamada, HY. and Gorbsky, GJ. 2006. Mol Cancer Ther. 5: 29-38. PMID: 16432160
6. MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway.  |  Inoue, T., et al. 2006. Biochem Biophys Res Commun. 342: 829-34. PMID: 16499872
7. The ubiquitin-proteasome system regulates p53-mediated transcription at p21waf1 promoter.  |  Zhu, Q., et al. 2007. Oncogene. 26: 4199-208. PMID: 17224908
8. Mouse homologue of yeast Prp19 interacts with mouse SUG1, the regulatory subunit of 26S proteasome.  |  Sihn, CR., et al. 2007. Biochem Biophys Res Commun. 356: 175-80. PMID: 17349974
9. SUG1, a putative transcriptional mediator and subunit of the PA700 proteasome regulatory complex, is a DNA helicase.  |  Fraser, RA., et al. 1997. J Biol Chem. 272: 7122-6. PMID: 9054406
10. SUG1, a component of the 26 S proteasome, is an ATPase stimulated by specific RNAs.  |  Makino, Y., et al. 1997. J Biol Chem. 272: 23201-5. PMID: 9287326
11. Proteasome-mediated degradation of the vitamin D receptor (VDR) and a putative role for SUG1 interaction with the AF-2 domain of VDR.  |  Masuyama, H. and MacDonald, PN. 1998. J Cell Biochem. 71: 429-40. PMID: 9831079
12. Adenovirus early region 1A protein binds to mammalian SUG1-a regulatory component of the proteasome.  |  Grand, RJ., et al. 1999. Oncogene. 18: 449-58. PMID: 9927201

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SUG1 Antibody (H-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-SUG1 Antibody (H-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SUG1 Antibody (H-7) Specifications

Alternate Product Name: SUG1

Product Clone Name: H-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 89-152

Epitope Target: SUG1

Epitope Species: human

Product Reactivity/Detection: SUG1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: avian

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for SUG1 Antibody (H-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin