STOP Antibody (175): sc-53513

STOP Antibody (175) is a mouse monoclonal IgG1 kappa light chain antibody that detects the STOP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). STOP (175) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. STOP protein plays a crucial role in stabilizing microtubules within the cytoplasm of mammalian cells, particularly in the context of cold-stable microtubules that resist depolymerization under extreme conditions. This stabilization is vital for maintaining cellular structure and function, especially in neurons where microtubule integrity is essential for axonal transport and overall cellular health. STOP protein consists of 952 amino acids, featuring five tandem repeats of 46 amino acids in its central region, which contribute to structural stability. Additionally, a SH3-binding motif located near the N-terminus of STOP protein facilitates interactions with other proteins, further underscoring importance in cellular dynamics. STOP protein′s ability to maintain microtubule stability even at temperatures as low as -80° C highlights significance in cellular resilience and adaptability, making anti-STOP antibody (175) an invaluable tool for researchers studying microtubule dynamics and neuronal function.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-STOP Antibody (175) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-STOP Antibody (175) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

STOP Antibody (175) Specifications

Alternate Product Name: STOP

Product Clone Name: 175

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: STOP

Epitope Species: rat

Product Reactivity/Detection: STOP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for STOP Antibody (175): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred STOP antibody is STOP Antibody (H-8): sc-137036.