Stomatin Antibody (E-6): sc-376920

Stomatin Antibody (E-6) is a mouse monoclonal IgG1 antibody that detects Stomatin in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Stomatin is an integral membrane protein predominantly located in lipid/protein-rich microdomains across nearly all human tissues, playing a crucial role in maintaining cellular integrity and function. Stomatin′s presence in these microdomains is vital for effective signal transduction and cell communication, as Stomatin may regulate the movement of cations through ion channels and transporters. Absence of Stomatin can lead to dysregulation of sodium and potassium ion concentrations within erythrocytes, potentially resulting in cellular dysfunction. Stomatin serves as a cytoskeletal anchor, contributing to the structural stability of cells. Stomatin is a major component of lipid rafts in erythrocytes and epithelial cells, and Stomatin is also found abundantly in platelets. Structurally, Stomatin features a single hydrophobic domain near its N-terminus, which is essential for membrane association, along with a phosphorylation site that may play a role in regulatory functions. Anti-Stomatin antibody (E-6) is an invaluable tool for researchers investigating the physiological and pathological roles of Stomatin in human health and disease.

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Stomatin Antibody (E-6) References:

1. Stomatin is a major lipid-raft component of platelet alpha granules.  |  Mairhofer, M., et al. 2002. Blood. 100: 897-904. PMID: 12130500
2. Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains.  |  Rungaldier, S., et al. 2013. Biochim Biophys Acta. 1828: 956-66. PMID: 23219802
3. Over-expression of stomatin causes syncytium formation in nonfusogenic JEG-3 choriocarcinoma placental cells.  |  Chen, TW., et al. 2016. Cell Biol Int. 40: 926-33. PMID: 27306251
4. Decreased expression of stomatin predicts poor prognosis in HER2-positive breast cancer.  |  Chen, CY., et al. 2016. BMC Cancer. 16: 697. PMID: 27577936
5. Mechanosensitive Pannexin 1 Activity Is Modulated by Stomatin in Human Red Blood Cells.  |  Rougé, S., et al. 2022. Int J Mol Sci. 23: PMID: 36012667
6. Stomatin-like Protein-2 Promotes Aggregation, Colonization and Migration of Endometriotic Cells.  |  Kumari, S., et al. 2023. Reprod Sci. 30: 1854-1866. PMID: 36484982
7. The Lipid Raft-Associated Protein Stomatin Is Required for Accumulation of Dectin-1 in the Phagosomal Membrane and for Full Activity of Macrophages against Aspergillus fumigatus.  |  Goldmann, M., et al. 2023. mSphere. 8: e0052322. PMID: 36719247
8. Stomatin promotes neutrophil degranulation and vascular leakage in the early stage after severe burn via enhancement of the intracellular binding of neutrophil primary granules to F-actin.  |  Zhu, Z., et al. 2024. Burns. 50: 653-665. PMID: 38185615
9. EphA-Mediated Regulation of Stomatin Expression in Prostate Cancer Cells.  |  Nishida, M., et al. 2024. Cancer Med. 13: e70276. PMID: 39377541
10. Stomatin: a putative cation transport regulator in the red cell membrane.  |  Stewart, GW., et al. 1993. Biochim Biophys Acta. 1225: 15-25. PMID: 7694657

The preferred Stomatin antibody is Stomatin Antibody (E-5): sc-376869.