STELLA Antibody (D-5): sc-376862

STELLA Antibody (D-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects STELLA protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). STELLA (D-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. STELLA protein, also known as Dppa3 and Pcg7, is a crucial member of the developmental pluripotency-associated protein family, playing a significant role in embryonic germ cell development. STELLA protein is predominantly expressed in the fetal ovary, with lower levels found in the testis and thymus, highlighting STELLA′s importance in germ cell differentiation and as a maternal factor that regulates early embryogenesis. STELLA protein is also implicated in tumor biology, as STELLA is overexpressed in testicular germ cell tumors, suggesting a potential role in tumor formation and making STELLA protein a promising candidate for early cancer detection. STELLA protein′s ability to interact with specific transcription factors and signaling pathways further underscores STELLA′s significance in both normal development and pathological conditions, making anti-STELLA antibody (D-5) an essential tool for researchers studying embryonic development and cancer biology.

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STELLA Antibody (D-5) References:

1. A molecular programme for the specification of germ cell fate in mice.  |  Saitou, M., et al. 2002. Nature. 418: 293-300. PMID: 12124616
2. Stella is a maternal effect gene required for normal early development in mice.  |  Payer, B., et al. 2003. Curr Biol. 13: 2110-7. PMID: 14654002
3. Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours.  |  Bowles, J., et al. 2003. Cytogenet Genome Res. 101: 261-5. PMID: 14684992
4. Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice.  |  Bortvin, A., et al. 2004. BMC Dev Biol. 4: 2. PMID: 15018652
5. Adult tissue-specific expression of a Dppa3-derived retrogene represents a postnatal transcript of pluripotent cell origin.  |  Elliman, SJ., et al. 2006. J Biol Chem. 281: 16-9. PMID: 16291741
6. Dazl deficiency leads to embryonic arrest of germ cell development in XY C57BL/6 mice.  |  Lin, Y. and Page, DC. 2005. Dev Biol. 288: 309-16. PMID: 16310179
7. IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion.  |  Tanaka, SS., et al. 2005. Dev Cell. 9: 745-56. PMID: 16326387
8. Diverse epigenetic profile of novel human embryonic stem cell lines.  |  Lagarkova, MA., et al. 2006. Cell Cycle. 5: 416-20. PMID: 16479162
9. Gene expression dynamics during germline specification in mice identified by quantitative single-cell gene expression profiling.  |  Yabuta, Y., et al. 2006. Biol Reprod. 75: 705-16. PMID: 16870942
10. Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition.  |  Huang, Y., et al. 2017. Elife. 6: PMID: 28323615
11. Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1.  |  Li, Y., et al. 2018. Nature. 564: 136-140. PMID: 30487604
12. Stella Regulates the Development of Female Germline Stem Cells by Modulating Chromatin Structure and DNA Methylation.  |  Hou, C., et al. 2022. Int J Biol Sci. 18: 3006-3018. PMID: 35541912

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-STELLA Antibody (D-5) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-STELLA Antibody (D-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

STELLA Antibody (D-5) Specifications

Alternate Product Name: STELLA

Product Clone Name: D-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-159

Epitope Target: STELLA

Epitope Species: human

Product Reactivity/Detection: STELLA

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for STELLA Antibody (D-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin