STC2 Antibody (2B11): sc-293388

STC2 Antibody (2B11) is a mouse monoclonal IgG2b kappa light chain antibody that detects STC2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-STC2 antibody (2B11) is available as a non-conjugated format. Stanniocalcin 2 (STC2) is a critical mammalian peptide hormone that plays a significant role in calcium and phosphate homeostasis, functioning as a regulator of mineral balance in the body. STC2 is primarily secreted by various tissues, including the kidneys and adrenal glands, where STC2 helps to modulate calcium levels in the bloodstream. STC2′s location in these tissues enables response to changes in calcium levels, thereby influencing physiological processes such as bone metabolism and cardiovascular health. STC2 interacts with specific proteins, including stanniocalcin 1 (STC1), which has opposing effects on calcium regulation, highlighting the delicate balance maintained by these hormones in the body. Phosphorylation of STC2 by casein kinase II (CK2) further underscores STC2′s regulatory capabilities, as this modification can enhance biological activity and influence interactions with other signaling pathways. STC2 (2B11) antibody is an essential tool for researchers studying the intricate roles of stanniocalcins in health and disease, particularly in conditions related to calcium dysregulation.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

STC2 Antibody (2B11) References:

1. Regulation by 1alpha,25-dihydroxyvitamin D(3) of expression of stanniocalcin messages in the rat kidney and ovary.  |  Honda, S., et al. 1999. FEBS Lett. 459: 119-22. PMID: 10508929
2. Expression of stanniocalcin in zona glomerulosa and medulla of normal human adrenal glands, and some adrenal tumors and cell lines.  |  Miura, W., et al. 2000. APMIS. 108: 367-72. PMID: 10937775
3. Stanniocalcin 1 and 2 are secreted as phosphoproteins from human fibrosarcoma cells.  |  Jellinek, DA., et al. 2000. Biochem J. 350 Pt 2: 453-61. PMID: 10947959
4. Stanniocalcin gene expression during mouse urogenital development: a possible role in mesenchymal-epithelial signalling.  |  Stasko, SE. and Wagner, GF. 2001. Dev Dyn. 220: 49-59. PMID: 11146507
5. Characterization of mammalian stanniocalcin receptors. Mitochondrial targeting of ligand and receptor for regulation of cellular metabolism.  |  McCudden, CR., et al. 2002. J Biol Chem. 277: 45249-58. PMID: 12223480
6. Regulation of stanniocalcin 1 and 2 expression in the kidney by klotho gene.  |  Yahata, K., et al. 2003. Biochem Biophys Res Commun. 310: 128-34. PMID: 14511659
7. Regulation of luteal cell big stanniocalcin production and secretion.  |  Paciga, M., et al. 2004. Endocrinology. 145: 4204-12. PMID: 15192041
8. Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties.  |  Ito, D., et al. 2004. Mol Cell Biol. 24: 9456-69. PMID: 15485913
9. Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2.  |  Chang, AC. and Reddel, RR. 1998. Mol Cell Endocrinol. 141: 95-9. PMID: 9723890

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-STC2 Antibody (2B11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-STC2 Antibody (2B11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

STC2 Antibody (2B11) Specifications

Alternate Product Name: STC2

Product Clone Name: 2B11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-302

Epitope Target: STC2

Epitope Species: human

Product Reactivity/Detection: STC2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for STC2 Antibody (2B11): N/A