STAU1 Antibody (H-11): sc-390992

STAU1 Antibody (H-11) is a mouse monoclonal IgG1 antibody that detects STAU1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). STAU1 is a 577 amino acid protein characterized by three double-stranded RNA-binding domains and serves as a mammalian homolog of the Drosophila Staufen protein, which is crucial for mRNA transport during oogenesis and zygotic development. STAU1 is primarily localized to the rough endoplasmic reticulum (RER) and is expressed across various tissues, including the heart, brain, liver, lung, pancreas, kidney, and placenta. STAU1 plays a vital role in mRNA transport from the microtubule network to the RER, binding to both tubulin and double-stranded RNA, which is essential for the proper positioning of mRNA during translation. Furthermore, STAU1 is involved in cross-linking cytoskeletal components with RNA, a process that is critical for maintaining the integrity of mRNA localization. Notably, alternative splicing of the STAU1 gene results in two isoforms, known as short and long, which may have distinct functional roles in cellular processes.

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STAU1 Antibody (H-11) References:

1. Interaction of Staufen1 with the 5' end of mRNA facilitates translation of these RNAs.  |  Dugré-Brisson, S., et al. 2005. Nucleic Acids Res. 33: 4797-812. PMID: 16126845
2. The RNA-binding protein Staufen1 is increased in DM1 skeletal muscle and promotes alternative pre-mRNA splicing.  |  Ravel-Chapuis, A., et al. 2012. J Cell Biol. 196: 699-712. PMID: 22431750
3. Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity.  |  Park, E., et al. 2013. Proc Natl Acad Sci U S A. 110: 405-12. PMID: 23263869
4. SMG1 regulates adipogenesis via targeting of staufen1-mediated mRNA decay.  |  Cho, H., et al. 2013. Biochim Biophys Acta. 1829: 1276-87. PMID: 24185201
5. Cell cycle-dependent regulation of the RNA-binding protein Staufen1.  |  Boulay, K., et al. 2014. Nucleic Acids Res. 42: 7867-83. PMID: 24906885
6. STAU1 binds to IBDV genomic double-stranded RNA and promotes viral replication via attenuation of MDA5-dependent β interferon induction.  |  Ye, C., et al. 2019. FASEB J. 33: 286-300. PMID: 29979632
7. Noncanonical immune response to the inhibition of DNA methylation by Staufen1 via stabilization of endogenous retrovirus RNAs.  |  Ku, Y., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 33762305
8. NF-κB-activated SPRY4-IT1 promotes cancer cell metastasis by downregulating TCEB1 mRNA via Staufen1-mediated mRNA decay.  |  Zhao, L., et al. 2021. Oncogene. 40: 4919-4929. PMID: 34163032
9. High Level of Staufen1 Expression Confers Longer Recurrence Free Survival to Non-Small Cell Lung Cancer Patients by Promoting THBS1 mRNA Degradation.  |  Bonnet-Magnaval, F., et al. 2021. Int J Mol Sci. 23: PMID: 35008641
10. Phosphomimicry on STAU1 Serine 20 Impairs STAU1 Posttranscriptional Functions and Induces Apoptosis in Human Transformed Cells.  |  Gonzalez Quesada, Y., et al. 2022. Int J Mol Sci. 23: PMID: 35806349

The preferred STAU1 antibody is STAU1 Antibody (C-4): sc-390820.