STAU1 Antibody (C-4): sc-390820

STAU1 Antibody (C-4) is a mouse monoclonal IgM antibody that detects STAU1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-STAU1 antibody (C-4) is available as a non-conjugated format. STAU1, also known as staufen, RNA binding protein, homolog 1, is a 577 amino acid protein characterized by three double-stranded RNA-binding domains, making STAU1 a crucial player in mRNA transport and localization regulation. STAU1 is primarily located in the rough endoplasmic reticulum (RER) and is expressed across various tissues, including heart, brain, liver, lung, pancreas, kidney, and placenta. STAU1 localization to RER facilitates mRNA transport from microtubule networks to translation sites, ensuring correct positioning for efficient protein synthesis. STAU1 interacts with both tubulin and double-stranded RNA, contributing to cross-linking cytoskeletal components with RNA, a process essential for maintaining proper mRNA positioning during translation. Alternative splicing of STAU1 results in two isoforms, referred to as short and long, which may have distinct functional roles in cellular processes.

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STAU1 Antibody (C-4) References:

1. Mammalian staufen is a double-stranded-RNA- and tubulin-binding protein which localizes to the rough endoplasmic reticulum.  |  Wickham, L., et al. 1999. Mol Cell Biol. 19: 2220-30. PMID: 10022909
2. Molecular mapping of the determinants involved in human Staufen-ribosome association.  |  Luo, M., et al. 2002. Biochem J. 365: 817-24. PMID: 12133005
3. Characterization of Staufen 1 ribonucleoprotein complexes.  |  Brendel, C., et al. 2004. Biochem J. 384: 239-46. PMID: 15303970
4. Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay.  |  Kim, YK., et al. 2005. Cell. 120: 195-208. PMID: 15680326
5. Staufen1 regulates diverse classes of mammalian transcripts.  |  Kim, YK., et al. 2007. EMBO J. 26: 2670-81. PMID: 17510634
6. A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes.  |  Furic, L., et al. 2008. RNA. 14: 324-35. PMID: 18094122
7. Characterization of a novel transcript variant of human STAU1 gene.  |  Fa-Hui, N., et al. 2008. Acta Biochim Pol. 55: 473-8. PMID: 18806890
8. Staufen1-mediated mRNA decay functions in adipogenesis.  |  Cho, H., et al. 2012. Mol Cell. 46: 495-506. PMID: 22503102
9. Staufen1-mediated mRNA decay induces Requiem mRNA decay through binding of Staufen1 to the Requiem 3'UTR.  |  Kim, MY., et al. 2014. Nucleic Acids Res. 42: 6999-7011. PMID: 24799437
10. Staufen1 and UPF1 exert opposite actions on the replacement of the nuclear cap-binding complex by eIF4E at the 5' end of mRNAs.  |  Jeong, K., et al. 2019. Nucleic Acids Res. 47: 9313-9328. PMID: 31361897
11. DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs.  |  Miao, W., et al. 2025. Cell Rep. 44: 115174. PMID: 39764852
12. Localization of a human double-stranded RNA-binding protein gene (STAU) to band 20q13.1 by fluorescence in situ hybridization.  |  DesGroseillers, L. and Lemieux, N. 1996. Genomics. 36: 527-9. PMID: 8884277

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-STAU1 Antibody (C-4) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-STAU1 Antibody (C-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

STAU1 Antibody (C-4) Specifications

Alternate Product Name: STAU1

Product Clone Name: C-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 458-577

Epitope Target: STAU1

Epitope Species: human

Product Reactivity/Detection: STAU1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for STAU1 Antibody (C-4): N/A