STAU1 Antibody (G-8): sc-377484

STAU1 Antibody (G-8) is a mouse monoclonal IgG1 antibody that detects STAU1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). STAU1 is a 577 amino acid protein characterized by three double-stranded RNA-binding domains and serves as a mammalian homolog of the Drosophila Staufen protein, which is crucial for mRNA transport during oogenesis and zygotic development. STAU1 is primarily localized to the rough endoplasmic reticulum (RER) and is expressed across various tissues, including the heart, brain, liver, lung, pancreas, kidney, and placenta. The localization of STAU1 to the RER is significant as STAU1 facilitates the transport of mRNA from the microtubule network to the site of translation, ensuring that mRNA is correctly positioned for efficient protein synthesis. Furthermore, STAU1 interacts with both tubulin and double-stranded RNA, and STAU1 may play a role in cross-linking cytoskeletal components with RNA, which is essential for maintaining proper mRNA positioning during translation. Notably, alternative splicing of the STAU1 gene results in two isoforms, referred to as short and long, which may have distinct functional roles in cellular processes. Anti-STAU1 antibody (G-8) is an invaluable tool for researchers studying mRNA transport mechanisms and the intricate regulation of gene expression.

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STAU1 Antibody (G-8) References:

1. Staufen1 senses overall transcript secondary structure to regulate translation.  |  Ricci, EP., et al. 2014. Nat Struct Mol Biol. 21: 26-35. PMID: 24336223
2. Lin28B and miR-142-3p regulate neuronal differentiation by modulating Staufen1 expression.  |  Oh, Y., et al. 2018. Cell Death Differ. 25: 432-443. PMID: 29099484
3. Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration.  |  Paul, S., et al. 2018. Nat Commun. 9: 3648. PMID: 30194296
4. HIV-1 requires Staufen1 to dissociate stress granules and to produce infectious viral particles.  |  Rao, S., et al. 2019. RNA. 25: 727-736. PMID: 30902835
5. Staufen1 reads out structure and sequence features in ARF1 dsRNA for target recognition.  |  Yadav, DK., et al. 2020. Nucleic Acids Res. 48: 2091-2106. PMID: 31875226
6. Staufen1 is Essential for Cell-Cycle Transitions and Cell Proliferation Via the Control of E2F1 Expression.  |  Ghram, M., et al. 2020. J Mol Biol. 432: 3881-3897. PMID: 32335035
7. Distinct roles for the RNA-binding protein Staufen1 in prostate cancer.  |  Marcellus, KA., et al. 2021. BMC Cancer. 21: 120. PMID: 33541283
8. Phosphomimicry on STAU1 Serine 20 Impairs STAU1 Posttranscriptional Functions and Induces Apoptosis in Human Transformed Cells.  |  Gonzalez Quesada, Y., et al. 2022. Int J Mol Sci. 23: PMID: 35806349
9. Staufen1 controls mitochondrial metabolism via HIF2α in embryonal rhabdomyosarcoma and promotes tumorigenesis.  |  Almasi, S., et al. 2023. Cell Mol Life Sci. 80: 328. PMID: 37847286
10. RNA-binding protein GIGYF2 orchestrates hepatic insulin resistance through STAU1/PTEN-mediated disruption of the PI3K/AKT signaling cascade.  |  Lv, Z., et al. 2024. Mol Med. 30: 124. PMID: 39138413

The preferred STAU1 antibody is STAU1 Antibody (C-4): sc-390820.