STAU1 Antibody (D-5): sc-376123
- STAU1 Antibody (D-5) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 185-217 within an internal region of STAU1 of human origin
- recommended for detection of STAU1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for STAU1 Antibody (D-5) for WB and IHC(P) applications. These reagents are now offered in bundles with STAU1 Antibody (D-5) (see ordering information below).
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STAU1 Antibody (D-5) is a mouse monoclonal IgG1 antibody that detects STAU1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). STAU1 is a 577 amino acid protein characterized by three double-stranded RNA-binding domains and serves as a mammalian homolog of the Drosophila Staufen protein, which is crucial for mRNA transport during oogenesis and zygotic development. STAU1 is primarily localized to the rough endoplasmic reticulum (RER) and is expressed across multiple tissues such as the heart, brain, liver, lung, pancreas, kidney, and placenta. STAU1 plays a vital role in mRNA transport by binding to both tubulin and double-stranded RNA, facilitating the movement of mRNA from the microtubule network to the RER. Furthermore, STAU1 is believed to be involved in cross-linking cytoskeletal components with RNA, a process essential for the accurate positioning of mRNA during translation, thereby influencing gene expression and cellular function. Alternative splicing of the STAU1 gene results in two isoforms, referred to as short and long, which may have distinct functional roles in cellular processes.
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STAU1 Antibody (D-5) References:
- Staufen1 Regulates Multiple Alternative Splicing Events either Positively or Negatively in DM1 Indicating Its Role as a Disease Modifier. | Bondy-Chorney, E., et al. 2016. PLoS Genet. 12: e1005827. PMID: 26824521
- Staufen1 Protein Participates Positively in the Viral RNA Replication of Enterovirus 71. | Chen, YM., et al. 2019. Viruses. 11: PMID: 30744035
- Staufen1 in Human Neurodegeneration. | Paul, S., et al. 2021. Ann Neurol. 89: 1114-1128. PMID: 33745139
- Differential regulation of autophagy by STAU1 in alveolar rhabdomyosarcoma and non-transformed skeletal muscle cells. | Almasi, S., et al. 2021. Cell Oncol (Dordr). 44: 851-870. PMID: 33899158
- The double-stranded RNA-binding protein, Staufen1, is an IRES-transacting factor regulating HIV-1 cap-independent translation initiation. | Ramos, H., et al. 2022. Nucleic Acids Res. 50: 411-429. PMID: 34893869
- A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation. | Gonzalez Quesada, Y. and DesGroseillers, L. 2022. Int J Mol Sci. 23: PMID: 36232890
- Effects of STAU1/staufen1 on autophagy in neurodegenerative diseases. | Pulst, SM., et al. 2023. Autophagy. 19: 2607-2608. PMID: 36652469
- Staufen1 Represses the FOXA1-Regulated Transcriptome by Destabilizing FOXA1 mRNA in Colorectal Cancer Cells. | Pasterczyk, KR., et al. 2024. Mol Cell Biol. 44: 43-56. PMID: 38347726
- STAU1 exhibits a dual function by promoting amyloidogenesis and tau phosphorylation in cultured cells. | Li, CL., et al. 2024. Exp Neurol. 377: 114805. PMID: 38729552
- Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration. | Zhao, R., et al. 2024. J Cell Biol. 223: PMID: 38913026
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
STAU1 Antibody (D-5) | sc-376123 | 200 µg/ml | $322.00 | |||
STAU1 Antibody (D-5): m-IgG Fc BP-HRP Bundle | sc-540518 | 200 µg Ab; 10 µg BP | $361.00 | |||
STAU1 Antibody (D-5): m-IgG1 BP-HRP Bundle | sc-542177 | 200 µg Ab; 20 µg BP | $361.00 | |||
STAU1 (D-5) Neutralizing Peptide | sc-376123 P | 100 µg/0.5 ml | $69.00 |