Stat4 Antibody (A-12): sc-365518
- Stat4 Antibody (A-12) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 129-153 near the N-terminus of Stat4 of human origin
- recommended for detection of Stat4 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-365518 X, 200 µg/0.1 ml)
- See Stat4 (C-4): sc-398228 for Stat4 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Stat4 Antibody (A-12) for WB applications. This reagent is now offered in a bundle with Stat4 Antibody (A-12) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
Stat4 Antibody (A-12) is a mouse monoclonal IgM kappa light chain antibody designed to detect the Signal Transducer and Activator of Transcription 4 (STAT4) protein, a pivotal member of the STAT family involved in cytokine signaling and immune response regulation. STAT4 monoclonal antibody (A-12) targets a unique epitope mapping between amino acids 129-153 near the N-terminus of human STAT4, ensuring precise recognition across mouse, rat, and human species. STAT4, also known as Signal Transducer and Activator of Transcription 4, is predominantly located in the cytoplasm and translocates to the nucleus upon activation by cytokines such as interleukin-12 (IL-12). This translocation is crucial as STAT4 functions as a transcription factor, regulating the expression of genes involved in the differentiation of naive T cells into Th1 cells, which are essential for mounting effective immune responses against intracellular pathogens and in the development of certain autoimmune diseases. Post-translational modifications, particularly tyrosine phosphorylation by Janus kinases (JAKs), are critical for STAT4 activation, enabling dimerization, DNA binding, and subsequent transcriptional activity. anti-STAT4 antibody (A-12) is validated for use in multiple applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA), making STAT4 (A-12) antibody a versatile tool for researchers studying the molecular mechanisms of immune cell differentiation, inflammatory pathways, and cytokine signaling. The high specificity and reliable performance of STAT4 monoclonal antibody (A-12) facilitate accurate detection and analysis of STAT4, supporting advancements in immunology, autoimmune disease research, and cancer biology. Whether investigating the pathways involved in immune regulation or exploring the roles of transcription factors in disease progression, anti-STAT4 antibody (A-12) provides the precision and consistency needed to achieve meaningful and reproducible results in your experiments.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Stat4 Antibody (A-12) | sc-365518 | 200 µg/ml | $322.00 | |||
Stat4 Antibody (A-12): m-IgGκ BP-HRP Bundle | sc-552010 | 200 µg Ab; 40 µg BP | $361.00 | |||
Stat4 (A-12) Neutralizing Peptide | sc-365518 P | 100 µg/0.5 ml | $69.00 | |||
Stat4 Antibody (A-12) X | sc-365518 X | 200 µg/0.1 ml | $322.00 |