Stat1 Antibody (C-111): sc-417
- Stat1 Antibody (C-111) is a mouse monoclonal IgG1 κ, cited in 143 publications, provided at 200 µg/ml
- epitope mapping between amino acids 613-739 of Stat1 of human origin
- Anti-Stat1 Antibody (C-111) is recommended for detection of Stat1 of mouse, rat and human origin by WB, IP and IF
- Anti-Stat1 Antibody (C-111) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for Gel Supershift and ChIP applications (sc-417 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Stat1 Antibody (C-111) for WB applications. These reagents are now offered in bundles with Stat1 Antibody (C-111) (see ordering information below).
Stat1 Antibody (C-111) is a mouse monoclonal IgG1 kappa light chain antibody that detects Stat1 protein of mouse, rat, and human origin through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Stat1 (C-111) antibody is offered in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. Stat1 protein plays a crucial role in mediating cellular responses to cytokines, particularly interferons, which are vital for immune response and antiviral defense. Upon activation by ligands such as interferons and growth factors, Stat1 undergoes tyrosine phosphorylation, allowing formation of a heterodimer with Stat2, which is part of the ISGF3 transcription factor complex that regulates expression of genes involved in immune responses. This function is essential for proper functioning of the immune system, as Stat1 helps coordinate cellular response to pathogens and stress signals. Stat1 monoclonal antibody (C-111) is an invaluable tool for researchers studying intricate signaling pathways that govern immune responses and role of Stat proteins in various biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Stat1 Antibody (C-111) References:
- MicroRNA-145 targets YES and STAT1 in colon cancer cells. | Gregersen, LH., et al. 2010. PLoS One. 5: e8836. PMID: 20098684
- Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis. | Sampaio, EP., et al. 2013. J Allergy Clin Immunol. 131: 1624-34. PMID: 23541320
- Targeting STAT1 in Both Cancer and Insulin Resistance Diseases. | Meng, C., et al. 2017. Curr Protein Pept Sci. 18: 181-188. PMID: 27855602
- Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling. | Zuo, Y., et al. 2020. Nat Commun. 11: 1146. PMID: 32123171
- Redox Regulation of STAT1 and STAT3 Signaling. | Butturini, E., et al. 2020. Int J Mol Sci. 21: PMID: 32987855
- STAT1 and Its Crucial Role in the Control of Viral Infections. | Tolomeo, M., et al. 2022. Int J Mol Sci. 23: PMID: 35456913
- Cytosolic TGM2 promotes malignant progression in gastric cancer by suppressing the TRIM21-mediated ubiquitination/degradation of STAT1 in a GTP binding-dependent modality. | Zhang, L., et al. 2023. Cancer Commun (Lond). 43: 123-149. PMID: 36353796
- Inborn errors of immunity with loss- and gain-of-function germline mutations in STAT1. | Asano, T., et al. 2023. Clin Exp Immunol. 212: 96-106. PMID: 36420581
- Dysregulated IFN-γ signals promote autoimmunity in STAT1 gain-of-function syndrome. | Largent, AD., et al. 2023. Sci Transl Med. 15: eade7028. PMID: 37406138
- STAT1 deficiency underlies a proinflammatory imprint of naive CD4+ T cells in spondyloarthritis. | Cherqaoui, B., et al. 2023. Front Immunol. 14: 1227281. PMID: 37920469
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Stat1 Antibody (C-111) | sc-417 | 200 µg/ml | $316.00 | |||
Stat1 Antibody (C-111): m-IgG Fc BP-HRP Bundle | sc-528108 | 200 µg Ab; 10 µg BP | $354.00 | |||
Stat1 Antibody (C-111): m-IgGκ BP-HRP Bundle | sc-520406 | 200 µg Ab, 40 µg BP | $354.00 | |||
Stat1 Antibody (C-111): m-IgG1 BP-HRP Bundle | sc-542763 | 200 µg Ab; 20 µg BP | $354.00 | |||
Stat1 Antibody (C-111) X | sc-417 X | 200 µg/0.1 ml | $316.00 | |||
Stat1 Antibody (C-111) AC | sc-417 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Stat1 Antibody (C-111) HRP | sc-417 HRP | 200 µg/ml | $316.00 | |||
Stat1 Antibody (C-111) FITC | sc-417 FITC | 200 µg/ml | $330.00 | |||
Stat1 Antibody (C-111) PE | sc-417 PE | 200 µg/ml | $343.00 | |||
Stat1 Antibody (C-111) Alexa Fluor® 488 | sc-417 AF488 | 200 µg/ml | $357.00 | |||
Stat1 Antibody (C-111) Alexa Fluor® 546 | sc-417 AF546 | 200 µg/ml | $357.00 | |||
Stat1 Antibody (C-111) Alexa Fluor® 594 | sc-417 AF594 | 200 µg/ml | $357.00 | |||
Stat1 Antibody (C-111) Alexa Fluor® 647 | sc-417 AF647 | 200 µg/ml | $357.00 | |||
Stat1 Antibody (C-111) Alexa Fluor® 680 | sc-417 AF680 | 200 µg/ml | $357.00 | |||
Stat1 Antibody (C-111) Alexa Fluor® 790 | sc-417 AF790 | 200 µg/ml | $357.00 |