Stat1 Antibody (C-136): sc-464

Stat1 Antibody (C-136) is a mouse monoclonal IgG1 kappa light chain antibody that detects Stat1 protein of mouse, rat, and human origin through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Stat1 (C-136) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. Stat1 protein plays a crucial role in mediating cellular responses to interferons and other cytokines, which are vital for the immune response and regulation of gene expression. Upon activation by ligands such as interferons, Stat1 undergoes tyrosine phosphorylation, allowing formation of a heterodimer with Stat2, which is part of the ISGF3 transcription factor complex that translocates to the nucleus to initiate transcription of interferon-stimulated genes. This process is essential for the antiviral response and the regulation of immune functions, highlighting the importance of Stat1 in maintaining cellular homeostasis and responding to external stimuli.

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Stat1 Antibody (C-136) References:

1. STAT1 and pathogens, not a friendly relationship.  |  Najjar, I. and Fagard, R. 2010. Biochimie. 92: 425-44. PMID: 20159032
2. Stat1 is an inducible transcriptional repressor of neural stem cells self-renewal program during neuroinflammation.  |  Imitola, J., et al. 2023. Front Cell Neurosci. 17: 1156802. PMID: 37663126
3. The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies.  |  Wang, W., et al. 2023. Front Immunol. 14: 1265818. PMID: 38022653
4. Human STAT1 gain of function with chronic mucocutaneous candidiasis: A comprehensive review for strengthening the connection between bedside observations and laboratory research.  |  Asano, T., et al. 2024. Immunol Rev. 322: 81-97. PMID: 38084635
5. Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3.  |  Qureshi, SA., et al. 1995. Proc Natl Acad Sci U S A. 92: 3829-33. PMID: 7537377
6. Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3.  |  Schaefer, TS., et al. 1995. Proc Natl Acad Sci U S A. 92: 9097-101. PMID: 7568080
7. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway.  |  Schindler, C. and Darnell, JE. 1995. Annu Rev Biochem. 64: 621-51. PMID: 7574495
8. Interleukin-3, erythropoietin, and prolactin activate a STAT5-like factor in lymphoid cells.  |  Pallard, C., et al. 1995. J Biol Chem. 270: 15942-5. PMID: 7608147
9. Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation.  |  Yamamoto, K., et al. 1994. Mol Cell Biol. 14: 4342-9. PMID: 8007943
10. An interleukin-4-induced transcription factor: IL-4 Stat.  |  Hou, J., et al. 1994. Science. 265: 1701-6. PMID: 8085155
11. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6.  |  Zhong, Z., et al. 1994. Science. 264: 95-8. PMID: 8140422
12. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.  |  Darnell, JE., et al. 1994. Science. 264: 1415-21. PMID: 8197455

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Stat1 Antibody (C-136) has 194 citations in a variety of scientific publications.

Primary antibodies like Anti-Stat1 Antibody (C-136) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Stat1 Antibody (C-136) Specifications

Alternate Product Name: Stat1

Product Clone Name: C-136

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 613-739

Epitope Target: Stat1

Epitope Species: human

Product Reactivity/Detection: Stat1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 194 citations in various scientific publications

Available Conjugates/Forms for Stat1 Antibody (C-136): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent