STARS Antibody (E-9): sc-393062
- STARS Antibody (E-9) is a mouse monoclonal IgG2a κ STARS antibody provided at 200 µg/ml
- raised against amino acids 82-381 mapping at the C-terminus of STARS of human origin
- STARS Antibody (E-9) is recommended for detection of STARS of human origin by WB, IP, IF and ELISA
- Anti-STARS Antibody (E-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for STARS Antibody (E-9) for WB applications. These reagents are now offered in bundles with STARS Antibody (E-9) (see ordering information below).
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SEE ALSO...
STARS Antibody (E-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects STARS protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). STARS (E-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. STARS, also known as striated muscle activator of Rho-dependent signaling or ABRA (Actin-binding Rho-activating protein), is a 381 amino acid cytoplasmic protein that plays a crucial role in muscle function and cellular signaling. STARS is primarily localized to the cytoskeleton, specifically within the I-band of the sarcomere and the sarcomeric structure between Z-lines, which is vital for maintaining the structural integrity and contractility of muscle fibers. By activating serum response factor (SRF)-dependent transcription, STARS influences gene expression related to muscle development and function, either through Rho-actin signaling pathways or by promoting the nuclear translocation of MRTF-A or MRTF-B. STARS has been shown to interact with proteins such as ABLIM1, ABLIM2, and ABLIM3, which further underscores its importance in cellular signaling networks. The gene encoding STARS is located on human chromosome 8, a region that encompasses nearly 146 million bases and is responsible for encoding approximately 800 genes, highlighting the complexity and significance of STARS in human biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
STARS Antibody (E-9) References:
- Chromosomes 8 and 10 workshop. | Wildenauer, DB. and Schwab, SG. 1999. Am J Med Genet. 88: 239-43. PMID: 10374738
- STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription. | Arai, A., et al. 2002. J Biol Chem. 277: 24453-9. PMID: 11983702
- Muscle-specific signaling mechanism that links actin dynamics to serum response factor. | Kuwahara, K., et al. 2005. Mol Cell Biol. 25: 3173-81. PMID: 15798203
- DNA sequence and analysis of human chromosome 8. | Nusbaum, C., et al. 2006. Nature. 439: 331-5. PMID: 16421571
- Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity. | Kuwahara, K., et al. 2007. J Clin Invest. 117: 1324-34. PMID: 17415416
- Regulation of STARS and its downstream targets suggest a novel pathway involved in human skeletal muscle hypertrophy and atrophy. | Lamon, S., et al. 2009. J Physiol. 587: 1795-803. PMID: 19255118
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
STARS Antibody (E-9) | sc-393062 | 200 µg/ml | $322.00 | |||
STARS Antibody (E-9): m-IgG Fc BP-HRP Bundle | sc-530343 | 200 µg Ab; 10 µg BP | $361.00 | |||
STARS Antibody (E-9): m-IgGκ BP-HRP Bundle | sc-523789 | 200 µg Ab, 40 µg BP | $361.00 | |||
STARS Antibody (E-9): m-IgG2a BP-HRP Bundle | sc-547486 | 200 µg Ab; 10 µg BP | $361.00 | |||
STARS Antibody (E-9) AC | sc-393062 AC | 500 µg/ml, 25% agarose | $424.00 | |||
STARS Antibody (E-9) HRP | sc-393062 HRP | 200 µg/ml | $322.00 | |||
STARS Antibody (E-9) FITC | sc-393062 FITC | 200 µg/ml | $336.00 | |||
STARS Antibody (E-9) PE | sc-393062 PE | 200 µg/ml | $349.00 | |||
STARS Antibody (E-9) Alexa Fluor® 488 | sc-393062 AF488 | 200 µg/ml | $364.00 | |||
STARS Antibody (E-9) Alexa Fluor® 546 | sc-393062 AF546 | 200 µg/ml | $364.00 | |||
STARS Antibody (E-9) Alexa Fluor® 594 | sc-393062 AF594 | 200 µg/ml | $364.00 | |||
STARS Antibody (E-9) Alexa Fluor® 647 | sc-393062 AF647 | 200 µg/ml | $364.00 | |||
STARS Antibody (E-9) Alexa Fluor® 680 | sc-393062 AF680 | 200 µg/ml | $364.00 | |||
STARS Antibody (E-9) Alexa Fluor® 790 | sc-393062 AF790 | 200 µg/ml | $364.00 |