STAMBP Antibody (F-1): sc-393408

STAMBP Antibody (F-1) is a mouse monoclonal IgG1 antibody that detects STAMBP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). STAMBP, also known as AMSH, is a 424 amino acid protein belonging to the peptidase M67C family and is ubiquitously expressed across various tissues. STAMBP functions as a zinc metalloprotease, specifically cleaving ′Lys-63′-linked polyubiquitin chains, which is crucial for regulating protein degradation and cellular signaling pathways. By opposing the ubiquitin-dependent sorting of receptors to lysosomes, STAMBP plays a significant role in signal transduction related to cell growth and Myc induction, particularly in response to interleukin-2 and granulocyte-macrophage colony-stimulating factor. Furthermore, STAMBP enhances bone morphogenetic protein signaling by counteracting the inhibitory effects of Smad6 and Smad7, thereby influencing developmental processes and tissue homeostasis. STAMBP′s structure includes the JAMM motif, which is essential for protease activity and is sensitive to inhibition by N-ethylmaleimide, highlighting the importance of structural integrity for functional activity. anti-STAMBP antibody (F-1) is an invaluable tool for researchers studying the intricate roles of STAMBP in cellular processes and signaling pathways.

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STAMBP Antibody (F-1) References:

1. Microcephaly-capillary malformation syndrome: Brothers with a homozygous STAMBP mutation, uncovered by exome sequencing.  |  Naseer, MI., et al. 2016. Am J Med Genet A. 170: 3018-3022. PMID: 27531570
2. High-throughput screening of functional deubiquitinating enzymes in autophagy.  |  Tian, S., et al. 2021. Autophagy. 17: 1367-1378. PMID: 32453962
3. [Resistant epileptic encephalopathy in a child with microcephalic capillary malformation syndrome].  |  Shchugareva, LM., et al. 2020. Zh Nevrol Psikhiatr Im S S Korsakova. 120: 110-116. PMID: 32929933
4. Further clinical delineation of microcephaly-capillary malformation syndrome.  |  Postma, JK., et al. 2022. Am J Med Genet A. 188: 3350-3357. PMID: 35962715
5. STAM binding protein regulated by hsa_circ_0007334 exerts oncogenic potential in pancreatic cancer.  |  Yu, S., et al. 2022. Pancreatology. 22: 1003-1012. PMID: 36089485
6. Integrated proteomics and genomics analysis of paradoxical eczema in psoriasis patients treated with biologics.  |  Al-Janabi, A., et al. 2023. J Allergy Clin Immunol. 152: 1237-1246. PMID: 37536512
7. Proteomic profiling identifies novel inflammation-related plasma proteins associated with ischemic stroke outcome.  |  Angerfors, A., et al. 2023. J Neuroinflammation. 20: 224. PMID: 37794467
8. Involvement of the OTUB1-YAP1 axis in driving malignant behaviors of head and neck squamous cell carcinoma.  |  Jin, S., et al. 2023. Cancer Med. 12: 22156-22169. PMID: 37986681
9. Can Biomarkers Correctly Predict Ventilator-associated Pneumonia in Patients Treated With Targeted Temperature Management After Cardiac Arrest? An Exploratory Study of the Multicenter Randomized Antibiotic (ANTHARTIC) Study.  |  Deye, N., et al. 2024. Crit Care Explor. 6: e1104. PMID: 38957212
10. Identification of STAM-binding protein as a target for the treatment of gemcitabine resistance pancreatic cancer in a nutrient-poor microenvironment.  |  Zhang, W., et al. 2024. Cell Death Dis. 15: 657. PMID: 39242557

The preferred STAMBP antibody is STAMBP Antibody (H-4): sc-271641.