STAMBP Antibody (C-1): sc-398480

STAMBP Antibody (C-1) is a mouse monoclonal IgG2a antibody that detects STAMBP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). STAMBP, also known as AMSH, is a 424 amino acid protein that belongs to the peptidase M67C family and is widely expressed across various tissues. STAMBP functions as a zinc metalloprotease, specifically cleaving ′Lys-63′-linked polyubiquitin chains, which is crucial for regulating protein degradation and cellular signaling pathways. By opposing the ubiquitin-dependent sorting of receptors to lysosomes, STAMBP plays a significant role in signal transduction related to cell growth and the induction of Myc, particularly in response to interleukin-2 and granulocyte-macrophage colony-stimulating factor. Furthermore, STAMBP enhances bone morphogenetic protein signaling by counteracting the inhibitory effects of Smad6 and Smad7, thereby influencing various developmental processes. STAMBP′s structure includes the JAMM motif, which is essential for protease activity and is sensitive to inhibition by N-ethylmaleimide, highlighting the importance of structural integrity for functional activity. Anti-STAMBP antibody (C-1) is an invaluable tool for researchers studying the intricate roles of STAMBP in cellular processes and signaling pathways.

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STAMBP Antibody (C-1) References:

1. Lysine 63-linked polyubiquitination is required for EGF receptor degradation.  |  Huang, F., et al. 2013. Proc Natl Acad Sci U S A. 110: 15722-7. PMID: 24019463
2. AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions.  |  Ribeiro-Rodrigues, TM., et al. 2014. FASEB J. 28: 4629-41. PMID: 25070368
3. Characterizing polyubiquitinated forms of the neurodegenerative ubiquitin mutant UBB+1.  |  Chojnacki, M., et al. 2016. FEBS Lett. 590: 4573-4585. PMID: 27861798
4. Inflammatory markers in late pregnancy in association with postpartum depression-A nested case-control study.  |  Bränn, E., et al. 2017. Psychoneuroendocrinology. 79: 146-159. PMID: 28285186
5. microRNA-378a-5p iS a novel positive regulator of melanoma progression.  |  Tupone, MG., et al. 2020. Oncogenesis. 9: 22. PMID: 32060259
6. Aberrant inflammatory profile in acute but not recovered anorexia nervosa.  |  Nilsson, IAK., et al. 2020. Brain Behav Immun. 88: 718-724. PMID: 32389698
7. Profiling of Inflammatory Proteins in Plasma of HIV-1-Infected Children Receiving Antiretroviral Therapy.  |  Lemma, M., et al. 2020. Proteomes. 8: PMID: 32906648
8. Agonist-activated glucagon receptors are deubiquitinated at early endosomes by two distinct deubiquitinases to facilitate Rab4a-dependent recycling.  |  Kaur, S., et al. 2020. J Biol Chem. 295: 16630-16642. PMID: 32967969
9. Multi-staged gene expression profiling reveals potential genes and the critical pathways in kidney cancer.  |  Khouja, HI., et al. 2022. Sci Rep. 12: 7240. PMID: 35508649
10. Mitochondrial DNA and inflammatory proteins are higher in extracellular vesicles from frail individuals.  |  Byappanahalli, AM., et al. 2023. Immun Ageing. 20: 6. PMID: 36710345

The preferred STAMBP antibody is STAMBP Antibody (H-4): sc-271641.