ST Antibody (H-8): sc-518084
- ST Antibody (H-8) is a mouse monoclonal IgG1 κ ST antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 69-88 within an N-terminal cytoplasmic domain of ST of human origin
- ST Antibody (H-8) is recommended for detection of ST of human origin by WB, IP, IF and ELISA
- Anti-ST Antibody (H-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ST Antibody (H-8) for WB applications. These reagents are now offered in bundles with ST Antibody (H-8) (see ordering information below).
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ST Antibody (H-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects the ST protein (serotonin transporter, also called SERT) of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ST antibody (H-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ST protein plays a crucial role in the reuptake of serotonin from the synaptic cleft, which is essential for regulating mood and emotional responses. By clearing serotonin, ST protein helps maintain the balance of neurotransmitters in the brain, and dysfunction of ST protein is linked to various psychiatric disorders, including depression and anxiety. Notably, many antidepressants, such as tricyclics and selective serotonin reuptake inhibitors (SSRIs), target ST protein to prolong serotonin availability in the synaptic cleft, thereby enhancing mood and emotional stability. The importance of ST protein in emotional development underscores its relevance in both basic neuroscience and clinical applications, making ST monoclonal antibody (H-8) a valuable tool for researchers studying serotonin signaling pathways and their implications in mental health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ST Antibody (H-8) References:
- Lack of association between serotonin transporter gene promoter variants and autistic disorder in two ethnically distinct samples. | Persico, AM., et al. 2000. Am J Med Genet. 96: 123-7. PMID: 10686565
- Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase. | Levy, FO., et al. 1992. FEBS Lett. 296: 201-6. PMID: 1733778
- Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells. | Cotecchia, S., et al. 1990. J Biol Chem. 265: 63-9. PMID: 2152928
- Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport. | Coleman, JA., et al. 2019. Nature. 569: 141-145. PMID: 31019304
- Disruption of the Mucosal Serotonin Reuptake Transporter (SERT) Through Gut Dysbiosis. | Zhou, Q. and Verne, GN. 2022. Gastroenterology. 162: 1833-1834. PMID: 35341788
- Design of fast-onset antidepressant by dissociating SERT from nNOS in the DRN. | Sun, N., et al. 2022. Science. 378: 390-398. PMID: 36302033
- Regulation of the human serotonin transporter by interleukin-1 beta. | Ramamoorthy, S., et al. 1995. Biochem Biophys Res Commun. 216: 560-7. PMID: 7488148
- The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor. | Barak, LS., et al. 1995. Biochemistry. 34: 15407-14. PMID: 7492540
- Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. | Ramamoorthy, S., et al. 1993. Proc Natl Acad Sci U S A. 90: 2542-6. PMID: 7681602
- Mammalian ion-coupled solute transporters. | Hediger, MA., et al. 1995. J Physiol. 482: 7S-17S. PMID: 7730974
- Phosphoinositide system-linked serotonin receptor subtypes and their pharmacological properties and clinical correlates. | Pandey, SC., et al. 1995. J Psychiatry Neurosci. 20: 215-25. PMID: 7786883
- Polymorphism in serotonin transporter gene associated with susceptibility to major depression. | Ogilvie, AD., et al. 1996. Lancet. 347: 731-3. PMID: 8602004
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ST Antibody (H-8) | sc-518084 | 200 µg/ml | $322.00 | |||
ST Antibody (H-8): m-IgG Fc BP-HRP Bundle | sc-531611 | 200 µg Ab; 10 µg BP | $361.00 | |||
ST Antibody (H-8): m-IgGκ BP-HRP Bundle | sc-525355 | 200 µg Ab, 40 µg BP | $361.00 | |||
ST Antibody (H-8): m-IgG1 BP-HRP Bundle | sc-544654 | 200 µg Ab; 20 µg BP | $361.00 | |||
ST Antibody (H-8) AC | sc-518084 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ST Antibody (H-8) HRP | sc-518084 HRP | 200 µg/ml | $322.00 | |||
ST Antibody (H-8) FITC | sc-518084 FITC | 200 µg/ml | $336.00 | |||
ST Antibody (H-8) PE | sc-518084 PE | 200 µg/ml | $349.00 | |||
ST Antibody (H-8) Alexa Fluor® 488 | sc-518084 AF488 | 200 µg/ml | $364.00 | |||
ST Antibody (H-8) Alexa Fluor® 546 | sc-518084 AF546 | 200 µg/ml | $364.00 | |||
ST Antibody (H-8) Alexa Fluor® 594 | sc-518084 AF594 | 200 µg/ml | $364.00 | |||
ST Antibody (H-8) Alexa Fluor® 647 | sc-518084 AF647 | 200 µg/ml | $364.00 | |||
ST Antibody (H-8) Alexa Fluor® 680 | sc-518084 AF680 | 200 µg/ml | $364.00 | |||
ST Antibody (H-8) Alexa Fluor® 790 | sc-518084 AF790 | 200 µg/ml | $364.00 |