SSSCA1 Antibody (G-12): sc-515430
- SSSCA1 Antibody (G-12) is a mouse monoclonal IgG2b κ SSSCA1 antibody provided at 200 µg/ml
- raised against amino acids 1-108 mapping at the N-terminus of SSSCA1 of human origin
- SSSCA1 Antibody (G-12) is recommended for detection of SSSCA1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-SSSCA1 Antibody (G-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SSSCA1 Antibody (G-12) for WB applications. These reagents are now offered in bundles with SSSCA1 Antibody (G-12) (see ordering information below).
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SSSCA1 Antibody (G-12) is a mouse monoclonal IgG2b kappa light chain antibody that detects SSSCA1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SSSCA1 (G-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SSSCA1, also known as Sjogren syndrome/scleroderma autoantigen 1 or p27, is a 199 amino acid protein that plays a crucial role in mitosis, functioning as a centromere-associated protein. This localization is significant because SSSCA1 is essential for proper chromosome segregation during cell division, and any dysfunction in this process can lead to genomic instability, which is a hallmark of many cancers. Additionally, SSSCA1 is phosphorylated upon DNA damage by ataxia-telangiectasia mutated (ATM) or ATM and Rad3-related (ATR) kinases, highlighting SSSCA1′s involvement in cellular responses to genotoxic stress. The gene encoding SSSCA1 is located on human chromosome 11, a region that harbors over 1,400 genes and is implicated in various genetic disorders, including Jervell and Lange-Nielsen syndrome and Jacobsen syndrome.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SSSCA1 Antibody (G-12) References:
- The 11q terminal deletion disorder: a prospective study of 110 cases. | Grossfeld, PD., et al. 2004. Am J Med Genet A. 129A: 51-61. PMID: 15266616
- Human chromosome 11 DNA sequence and analysis including novel gene identification. | Taylor, TD., et al. 2006. Nature. 440: 497-500. PMID: 16554811
- KCNQ1 K+ channel-mediated cardiac channelopathies. | Loussouarn, G., et al. 2006. Methods Mol Biol. 337: 167-83. PMID: 16929947
- Skipping of Exon 1 in the KCNQ1 gene causes Jervell and Lange-Nielsen syndrome. | Zehelein, J., et al. 2006. J Biol Chem. 281: 35397-403. PMID: 16987820
- Beta-thalassaemia and sickle cell anaemia as paradigms of hypercoagulability. | Ataga, KI., et al. 2007. Br J Haematol. 139: 3-13. PMID: 17854302
- The subcellular localization of the Niemann-Pick Type C proteins depends on the adaptor complex AP-3. | Berger, AC., et al. 2007. J Cell Sci. 120: 3640-52. PMID: 17895371
- Wilms tumour: prognostic factors, staging, therapy and late effects. | Kaste, SC., et al. 2008. Pediatr Radiol. 38: 2-17. PMID: 18026723
- Activation and regulation of ATM kinase activity in response to DNA double-strand breaks. | Lee, JH. and Paull, TT. 2007. Oncogene. 26: 7741-8. PMID: 18066086
- Targeted cancer therapies based on the inhibition of DNA strand break repair. | O'Connor, MJ., et al. 2007. Oncogene. 26: 7816-24. PMID: 18066095
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SSSCA1 Antibody (G-12) | sc-515430 | 200 µg/ml | $316.00 | |||
SSSCA1 Antibody (G-12): m-IgG Fc BP-HRP Bundle | sc-531363 | 200 µg Ab; 10 µg BP | $354.00 | |||
SSSCA1 Antibody (G-12): m-IgGκ BP-HRP Bundle | sc-525035 | 200 µg Ab, 40 µg BP | $354.00 | |||
SSSCA1 Antibody (G-12): m-IgG2b BP-HRP Bundle | sc-550283 | 200 µg Ab; 10 µg BP | $354.00 | |||
SSSCA1 Antibody (G-12) AC | sc-515430 AC | 500 µg/ml, 25% agarose | $416.00 | |||
SSSCA1 Antibody (G-12) HRP | sc-515430 HRP | 200 µg/ml | $316.00 | |||
SSSCA1 Antibody (G-12) FITC | sc-515430 FITC | 200 µg/ml | $330.00 | |||
SSSCA1 Antibody (G-12) PE | sc-515430 PE | 200 µg/ml | $343.00 | |||
SSSCA1 Antibody (G-12) Alexa Fluor® 488 | sc-515430 AF488 | 200 µg/ml | $357.00 | |||
SSSCA1 Antibody (G-12) Alexa Fluor® 546 | sc-515430 AF546 | 200 µg/ml | $357.00 | |||
SSSCA1 Antibody (G-12) Alexa Fluor® 594 | sc-515430 AF594 | 200 µg/ml | $357.00 | |||
SSSCA1 Antibody (G-12) Alexa Fluor® 647 | sc-515430 AF647 | 200 µg/ml | $357.00 | |||
SSSCA1 Antibody (G-12) Alexa Fluor® 680 | sc-515430 AF680 | 200 µg/ml | $357.00 | |||
SSSCA1 Antibody (G-12) Alexa Fluor® 790 | sc-515430 AF790 | 200 µg/ml | $357.00 |