SR-2C Antibody (D-12): sc-17797

SR-2C Antibody (D-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects SR-2C protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). SR-2C (D-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SR-2C protein, also known as 5-Hydroxytryptamine Receptor 2C, is a member of the G protein-coupled receptor family and plays a crucial role in mediating serotonin effects, a key neurotransmitter involved in numerous physiological processes. Located primarily in the central nervous system, SR-2C protein is essential for regulating mood, anxiety, and appetite, and has been implicated in the mechanisms of action of various atypical antipsychotic medications. SR-2C protein′s ability to activate phospholipase C and release intracellular calcium stores is vital for function, as SR-2C influences neuronal signaling pathways that affect behavior and emotional responses. Additionally, SR-2C protein′s interactions with other serotonin receptors, such as SR-2A and SR-2B, highlight importance in the broader context of serotonin signaling and potential impact on psychiatric disorders, making anti-SR-2C antibody (D-12) an invaluable tool for researchers studying these complex biological systems.

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SR-2C Antibody (D-12) References:

1. Cellular localization of serotonin(2A) (5HT(2A)) receptors in the rat brain.  |  Xu, T. and Pandey, SC. 2000. Brain Res Bull. 51: 499-505. PMID: 10758340
2. Serotonin 2B receptor is required for heart development.  |  Nebigil, CG., et al. 2000. Proc Natl Acad Sci U S A. 97: 9508-13. PMID: 10944220
3. Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors.  |  Herrick-Davis, K., et al. 2000. J Pharmacol Exp Ther. 295: 226-32. PMID: 10991983
4. Role of 5-HT in the regulation of the brain-pituitary-adrenal axis: effects of 5-HT on adrenocortical cells.  |  Contesse, V., et al. 2000. Can J Physiol Pharmacol. 78: 967-83. PMID: 11149386
5. Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice.  |  Gingrich, JA. and Hen, R. 2001. Psychopharmacology (Berl). 155: 1-10. PMID: 11374326
6. Therapeutic Potential of 5-HT2C Receptor Agonists for Addictive Disorders.  |  Higgins, GA. and Fletcher, PJ. 2015. ACS Chem Neurosci. 6: 1071-88. PMID: 25870913
7. Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction.  |  Felsing, DE., et al. 2018. PLoS One. 13: e0203137. PMID: 30157263
8. Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior.  |  He, Y., et al. 2022. Nat Med. 28: 2537-2546. PMID: 36536256
9. Hippocampal excitation-inhibition balance underlies the 5-HT2C receptor in modulating depressive behaviours.  |  Shi, HJ., et al. 2024. Brain. 147: 3764-3779. PMID: 38701344
10. Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans.  |  Liu, H., et al. 2024. Sci Adv. 10: eadl2675. PMID: 38941473
11. Contractile serotonin-2A receptor signal transduction in guinea pig trachea: importance of protein kinase C and extracellular and intracellular calcium but not phosphoinositide hydrolysis.  |  Watts, SW., et al. 1994. J Pharmacol Exp Ther. 271: 832-44. PMID: 7965803
12. Signaling pathways mediating induction of the early response genes prostaglandin G/H synthase-2 and egr-1 by serotonin via 5-HT2A receptors.  |  Goppelt-Struebe, M. and Stroebel, M. 1998. J Cell Physiol. 175: 341-7. PMID: 9572479

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SR-2C Antibody (D-12) has 43 citations in a variety of scientific publications.

Primary antibodies like Anti-SR-2C Antibody (D-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SR-2C Antibody (D-12) Specifications

Alternate Product Name: HTR2C

Product Clone Name: D-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 374-458

Epitope Target: serotonin receptor 2C

Epitope Species: human

Product Reactivity/Detection: serotonin 2C receptor (5-HT2C)

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 43 citations in various scientific publications

Available Conjugates/Forms for SR-2C Antibody (D-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin