spectrin β IV Antibody (D-7): sc-514744
- spectrin β IV Antibody (D-7) is a mouse monoclonal IgM κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2351-2369 near the C-terminus of spectrin β IV of human origin
- recommended for detection of spectrin β IV isoforms 1 and 3 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for spectrin β IV Antibody (D-7). This work is in progress.
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spectrin β IV Antibody (D-7) is a mouse monoclonal IgM antibody that detects spectrin β IV in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Spectrin β IV is a crucial member of the β-spectrin family, primarily expressed in the brain and pancreatic islets, where spectrin β IV plays a significant role in maintaining cellular integrity and organization. This 2,564 amino acid protein is notable for its four isoforms, which arise from alternative splicing, allowing for functional diversity in various cellular contexts. Spectrin β IV is localized to the nuclear matrix, cytoplasmic vesicles, and PML nuclear bodies, highlighting spectrin β IV′s importance in cellular architecture and signaling pathways. Spectrin β IV′s interaction with other cytoskeletal components and role in organizing the cytoskeleton are vital for processes such as cell shape maintenance, intracellular transport, and signal transduction, making anti-spectrin β IV antibody (D-7) an essential tool for researchers studying these critical biological functions.
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spectrin β IV Antibody (D-7) References:
- DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease. | Sanchez-Mut, JV., et al. 2013. Brain. 136: 3018-27. PMID: 24030951
- A recessive mutation in beta-IV-spectrin (SPTBN4) associates with congenital myopathy, neuropathy, and central deafness. | Knierim, E., et al. 2017. Hum Genet. 136: 903-910. PMID: 28540413
- A novel homozygous splice-site mutation in the SPTBN4 gene causes axonal neuropathy without intellectual disability. | Häusler, MG., et al. 2020. Eur J Med Genet. 63: 103826. PMID: 31857255
- Tbx5 variants disrupt Nav1.5 function differently in patients diagnosed with Brugada or Long QT Syndrome. | Nieto-Marín, P., et al. 2022. Cardiovasc Res. 118: 1046-1060. PMID: 33576403
- Novel bi-allelic variants expand the SPTBN4-related genetic and phenotypic spectrum. | Buelow, M., et al. 2021. Eur J Hum Genet. 29: 1121-1128. PMID: 33772159
- Heterozygous variants in SPTBN1 cause intellectual disability and autism. | Rosenfeld, JA., et al. 2021. Am J Med Genet A. 185: 2037-2045. PMID: 33847457
- Loss of β4-spectrin impairs Nav channel clustering at the heminode and temporal fidelity of presynaptic spikes in developing auditory brain. | Nip, K., et al. 2022. Sci Rep. 12: 5854. PMID: 35393465
- SPTBN5, Encoding the βV-Spectrin Protein, Leads to a Syndrome of Intellectual Disability, Developmental Delay, and Seizures. | Khan, A., et al. 2022. Front Mol Neurosci. 15: 877258. PMID: 35782384
- Spectrins: molecular organizers and targets of neurological disorders. | Lorenzo, DN., et al. 2023. Nat Rev Neurosci. 24: 195-212. PMID: 36697767
- Postsynaptic β1 spectrin maintains Na+ channels at the neuromuscular junction. | Sert, O., et al. 2024. J Physiol. 602: 1127-1145. PMID: 38441922
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
spectrin β IV Antibody (D-7) | sc-514744 | 200 µg/ml | $322.00 | |||
spectrin β IV (D-7) Neutralizing Peptide | sc-514744 P | 100 µg/0.5 ml | $69.00 |