spectrin β II Antibody (H-5): sc-374125
- spectrin β II Antibody (H-5) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2229-2261 near the C-terminus of spectrin β II of human origin
- recommended for detection of spectrin β II of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine and bovine
- m-IgG3 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for spectrin β II Antibody (H-5) for WB applications. These reagents are now offered in bundles with spectrin β II Antibody (H-5) (see ordering information below).
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spectrin β II Antibody (H-5) is a mouse monoclonal IgG3 antibody that detects spectrin β II in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Spectrin β II plays a crucial role in maintaining the structural integrity and organization of the cytoskeleton, particularly in non-erythroid cells, where spectrin β II contributes to the dynamic regulation of cellular shape and mechanical properties. Spectrin β II is primarily located in the cytoplasm and is essential for the formation of spectrin-actin networks that provide support to the plasma membrane, facilitating processes such as cell signaling and movement. Additionally, spectrin β II is known to interact with calmodulin in a calcium-dependent manner, linking spectrin β II to the regulation of cytoskeletal dynamics in response to calcium fluctuations, which is vital for various cellular functions including secretion and motility. The human SPTBN1 gene encodes the nonerythroid form of β-spectrin, underscoring spectrin β II′s importance in a wide range of physiological processes. Anti-spectrin β II antibody (H-5) is an invaluable tool for researchers studying cytoskeletal organization and dynamics in various biological contexts.
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spectrin β II Antibody (H-5) References:
- Non-erythroid beta spectrin interacting proteins and their effects on spectrin tetramerization. | Sevinc, A. and Fung, LW. 2011. Cell Mol Biol Lett. 16: 595-609. PMID: 21866423
- α-Synuclein modulates neurite outgrowth by interacting with SPTBN1. | Lee, HJ., et al. 2012. Biochem Biophys Res Commun. 424: 497-502. PMID: 22771809
- SPTBN1 suppresses the progression of epithelial ovarian cancer via SOCS3-mediated blockade of the JAK/STAT3 signaling pathway. | Chen, M., et al. 2020. Aging (Albany NY). 12: 10896-10911. PMID: 32516133
- SPTBN1 inhibits growth and epithelial-mesenchymal transition in breast cancer by downregulating miR-21. | Wu, H., et al. 2021. Eur J Pharmacol. 909: 174401. PMID: 34358482
- Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and Development. | Chen, S., et al. 2022. Cell Mol Gastroenterol Hepatol. 13: 949-973.e7. PMID: 34737104
- β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development. | Rao, S., et al. 2021. Sci Transl Med. 13: eabk2267. PMID: 34910547
- SPTBN1 attenuates rheumatoid arthritis synovial cell proliferation, invasion, migration and inflammatory response by binding to PIK3R2. | Dai, LP., et al. 2022. Immun Inflamm Dis. 10: e724. PMID: 36444616
- SPTBN1 abrogates renal clear cell carcinoma progression via glycolysis reprogramming in a GPT2-dependent manner. | Wu, J., et al. 2022. J Transl Med. 20: 603. PMID: 36527113
- Clinical significance of nonerythrocytic spectrin Beta 1 (SPTBN1) in human kidney renal clear cell carcinoma and uveal melanoma: a study based on Pan-Cancer Analysis. | Tang, W., et al. 2023. BMC Cancer. 23: 303. PMID: 37013511
- Interleukin-27-induced HIV-resistant dendritic cells suppress reveres transcription following virus entry in an SPTBN1, autophagy, and YB-1 independent manner. | Imamichi, T., et al. 2023. PLoS One. 18: e0287829. PMID: 37910521
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
spectrin β II Antibody (H-5) | sc-374125 | 200 µg/ml | $322.00 | |||
spectrin β II Antibody (H-5): m-IgGκ BP-HRP Bundle | sc-535391 | 200 µg Ab; 40 µg BP | $361.00 | |||
spectrin β II Antibody (H-5): m-IgG3 BP-HRP Bundle | sc-550308 | 200 µg Ab; 40 µg BP | $361.00 | |||
spectrin β II (H-5) Neutralizing Peptide | sc-374125 P | 100 µg/0.5 ml | $69.00 |