spectrin β I Antibody (D-6): sc-376859

Spectrin β I Antibody (D-6) is a mouse monoclonal IgG1 antibody that detects spectrin β I in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Spectrin β I plays a crucial role in maintaining the structural integrity and stability of the cytoskeleton, particularly in erythrocytes, where spectrin β I forms part of the spectrin cytoskeletal network that underpins the plasma membrane. Spectrin β I is essential for preserving the unique biconcave shape of red blood cells, which is vital for their ability to deform and navigate through narrow capillaries, thereby facilitating efficient oxygen transport throughout the body. Spectrin β I interacts with various other cytoskeletal components, including actin and other spectrin isoforms, to form a dynamic and resilient network that responds to mechanical stress. Understanding the function and interactions of spectrin β I is important for elucidating the mechanisms underlying various hematological disorders and for developing potential therapeutic strategies. Anti-spectrin β I antibody (D-6) is an invaluable tool for researchers investigating the cytoskeletal dynamics and membrane properties in a range of biological contexts.

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spectrin β I Antibody (D-6) References:

1. Non-erythroid beta spectrin interacting proteins and their effects on spectrin tetramerization.  |  Sevinc, A. and Fung, LW. 2011. Cell Mol Biol Lett. 16: 595-609. PMID: 21866423
2. The Prediction of the Expected Current Selection Coefficient of Single Nucleotide Polymorphism Associated with Holstein Milk Yield, Fat and Protein Contents.  |  Lee, YS., et al. 2016. Asian-Australas J Anim Sci. 29: 36-42. PMID: 26732326
3. New molecular insights into modulation of platelet reactivity in aspirin-treated patients using a network-based approach.  |  Zufferey, A., et al. 2016. Hum Genet. 135: 403-414. PMID: 26883867
4. Glial βII Spectrin Contributes to Paranode Formation and Maintenance.  |  Susuki, K., et al. 2018. J Neurosci. 38: 6063-6075. PMID: 29853631
5. Identification of differentially expressed genes and functional annotations associated with metastases of the uveal melanoma.  |  Xu, Y., et al. 2019. J Cell Biochem. 120: 19202-19214. PMID: 31270856
6. Analysis of recent shared ancestry in a familial cohort identifies coding and noncoding autism spectrum disorder variants.  |  Tuncay, IO., et al. 2022. NPJ Genom Med. 7: 13. PMID: 35190550
7. SPTBN1 Mediates the Cytoplasmic Constraint of PTTG1, Impairing Its Oncogenic Activity in Human Seminoma.  |  Teveroni, E., et al. 2023. Int J Mol Sci. 24: PMID: 38069214
8. Identification of bone mineral density associated genes with shared genetic architectures across multiple tissues: Functional insights for EPDR1, PKDCC, and SPTBN1.  |  Jung, J. and Wu, Q. 2024. PLoS One. 19: e0300535. PMID: 38683846
9. Age-Related Hearing Impairment: Genome and Blood Methylome Data Integration Reveals Candidate Epigenetic Biomarkers.  |  Yu, J., et al. 2024. OMICS. 28: 620-631. PMID: 39585213
10. Assignment of a locus (GLC3A) for primary congenital glaucoma (Buphthalmos) to 2p21 and evidence for genetic heterogeneity.  |  Sarfarazi, M., et al. 1995. Genomics. 30: 171-7. PMID: 8586416

The preferred spectrin β I antibody is spectrin β I Antibody (B-1): sc-374309.