spectrin β I Antibody (A-12): sc-374308
- spectrin β I Antibody (A-12) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2111-2137 at the C-terminus of spectrin β I of human origin
- recommended for detection of spectrin β I of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for spectrin β I Antibody (A-12). This work is in progress.
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spectrin β I Antibody (A-12) is a mouse monoclonal IgG2a antibody that detects spectrin β I in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Spectrin β I plays a crucial role in maintaining the structural integrity and stability of the cytoskeleton, particularly in erythrocytes, where spectrin β I forms part of the spectrin-actin network that underpins the plasma membrane. This network is vital for preserving the biconcave shape of red blood cells, which is essential for their flexibility and ability to navigate through the microvasculature. The proper functioning of spectrin β I is not only important for erythrocyte morphology but also for cellular signaling and the organization of membrane proteins, which can influence various physiological processes. Disruption of spectrin β I function can lead to a range of hematological disorders, highlighting spectrin β I′s significance in both health and disease. anti-spectrin β I antibody (A-12) is an invaluable tool for researchers studying the dynamics of the cytoskeleton and its implications in cellular function and pathology.
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spectrin β I Antibody (A-12) References:
- Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women. | Liu, JM., et al. 2010. J Clin Endocrinol Metab. 95: E112-20. PMID: 20554715
- Key amino acid residues of ankyrin-sensitive phosphatidylethanolamine/phosphatidylcholine-lipid binding site of βI-spectrin. | Wolny, M., et al. 2011. PLoS One. 6: e21538. PMID: 21738695
- Identification of miR-145 targets through an integrated omics analysis. | Huang, TC., et al. 2015. Mol Biosyst. 11: 197-207. PMID: 25354783
- Anaplastic Lymphoma Kinase Rearrangement in Digestive Tract Cancer: Implication for Targeted Therapy in Chinese Population. | Ying, J., et al. 2015. PLoS One. 10: e0144731. PMID: 26678488
- The RSPO3 gene as genetic markers for bone mass assessed by quantitative ultrasound in a population of young adults. | Correa-Rodríguez, M., et al. 2018. Ann Hum Genet. 82: 143-149. PMID: 29230809
- SPTBN1 suppresses the progression of epithelial ovarian cancer via SOCS3-mediated blockade of the JAK/STAT3 signaling pathway. | Chen, M., et al. 2020. Aging (Albany NY). 12: 10896-10911. PMID: 32516133
- RNA Modification-Related Genetic Variants in Genomic Loci Associated with Bone Mineral Density and Fracture. | Han, L., et al. 2022. Genes (Basel). 13: PMID: 36292776
- SPTBN1 attenuates rheumatoid arthritis synovial cell proliferation, invasion, migration and inflammatory response by binding to PIK3R2. | Dai, LP., et al. 2022. Immun Inflamm Dis. 10: e724. PMID: 36444616
- Clinical significance of nonerythrocytic spectrin Beta 1 (SPTBN1) in human kidney renal clear cell carcinoma and uveal melanoma: a study based on Pan-Cancer Analysis. | Tang, W., et al. 2023. BMC Cancer. 23: 303. PMID: 37013511
- Shared Genetic Architecture between Muscle and Bone: Identification and Functional Implications of EPDR1, PKDCC, and SPTBN1. | Jung, J. and Wu, Q. 2023. bioRxiv.. PMID: 37292779
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
spectrin β I Antibody (A-12) | sc-374308 | 200 µg/ml | $322.00 | |||
spectrin β I (A-12) Neutralizing Peptide | sc-374308 P | 100 µg/0.5 ml | $69.00 |