spectrin α II Antibody (C-11): sc-46696

spectrin α II Antibody (C-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects spectrin α II in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-spectrin α II antibody (C-11) is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. spectrin α II, also known as fodrin α, plays a crucial role in maintaining the structural integrity of the cytoskeleton in non-erythroid cells, where spectrin α II is primarily located in the cytoplasm. spectrin α II is essential for the organization and stabilization of the cell membrane, as spectrin α II forms a network that supports cellular shape and mechanical properties. The spectrin cytoskeletal network is vital for various cellular processes, including cell signaling, motility, and maintaining the overall architecture of the cell. Additionally, spectrin α II interacts with other cytoskeletal proteins, such as actin and various membrane proteins, which further emphasizes spectrin α II′s importance in cellular dynamics and integrity. The breakdown of spectrin α II by calpain activation can lead to significant alterations in neuronal structure, highlighting spectrin α II′s role in neurodegenerative processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

spectrin α II Antibody (C-11) References:

1. Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site.  |  Bignone, PA. and Baines, AJ. 2003. Biochem J. 374: 613-24. PMID: 12820899
2. Upregulation of dihydropyrimidinase-related protein 2, spectrin alpha II chain, heat shock cognate protein 70 pseudogene 1 and tropomodulin 2 after focal cerebral ischemia in rats--a proteomics approach.  |  Chen, A., et al. 2007. Neurochem Int. 50: 1078-86. PMID: 17196711
3. Effects of TRH and its analogues on primary cortical neuronal cell damage induced by various excitotoxic, necrotic and apoptotic agents.  |  Jantas, D., et al. 2009. Neuropeptides. 43: 371-85. PMID: 19666192
4. Characterization and expression of a heart-selective alternatively spliced variant of alpha II-spectrin, cardi+, during development in the rat.  |  Zhang, Y., et al. 2010. J Mol Cell Cardiol. 48: 1050-9. PMID: 20114050
5. Serum SNTF, a Surrogate Marker of Axonal Injury, Is Prognostic for Lasting Brain Dysfunction in Mild TBI Treated in the Emergency Department.  |  Siman, R., et al. 2020. Front Neurol. 11: 249. PMID: 32322237
6. Progressive Ataxia, Memory Impairments, and Seizure Episodes in Spna2 R1098Q Mouse Variant Affecting Alpha II Spectrin's Scaffold Stability.  |  Zalas, M., et al. 2023. Brain Sci. 13: PMID: 36831804
7. Erk Inhibition as a Promising Therapeutic Strategy for High IL-8-Secreting and Low SPTAN1-Expressing Colorectal Cancer.  |  Meier, C., et al. 2024. Int J Mol Sci. 25: PMID: 38891846
8. Abnormal spectrin in hereditary elliptocytosis.  |  Marchesi, SL., et al. 1986. Blood. 67: 141-51. PMID: 3940543
9. Pathologic and nonpathologic variants of the spectrin molecule in two black families with hereditary elliptocytosis.  |  Lecomte, MC., et al. 1985. Hum Genet. 71: 351-7. PMID: 4077050
10. The 270 kDa splice variant of erythrocyte beta-spectrin (beta I sigma 2) segregates in vivo and in vitro to specific domains of cerebellar neurons.  |  Malchiodi-Albedi, F., et al. 1993. J Cell Sci. 106 (Pt 1): 67-78. PMID: 8270644

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-spectrin α II Antibody (C-11) has 31 citations in a variety of scientific publications.

Primary antibodies like Anti-spectrin α II Antibody (C-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

spectrin α II Antibody (C-11) Specifications

Alternate Product Name: spectrin α II

Product Clone Name: C-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2368-2472

Epitope Target: spectrin α II

Epitope Species: human

Product Reactivity/Detection: spectrin α II

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 31 citations in various scientific publications

Available Conjugates/Forms for spectrin α II Antibody (C-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred spectrin α II antibody is spectrin α II Antibody (C-3): sc-48382.