spectrin α II Antibody (B-2): sc-376849

spectrin α II Antibody (B-2) is a mouse monoclonal IgG1 antibody that detects spectrin α II in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Spectrin α II, also known as fodrin α, plays a crucial role in maintaining the structural integrity of the cytoskeleton in non-erythroid cells, particularly in neurons, where anti-spectrin α II antibody (B-2) is essential for the organization of the axonal cytoskeleton and the stability of the plasma membrane. This protein is primarily located in the cytoplasm and is involved in the formation of a spectrin-actin network that supports cellular shape and mechanical resilience. The proper functioning of spectrin α II is vital for neuronal health, as spectrin α II (B-2) antibody helps to anchor membrane proteins and facilitates intracellular transport, thereby influencing synaptic function and plasticity. Additionally, spectrin α II undergoes post-translational modifications, such as phosphorylation, which can regulate interactions with other cytoskeletal components and signaling molecules, further underscoring importance in cellular dynamics and signaling pathways. spectrin α II monoclonal antibody (B-2) is an invaluable tool for researchers studying cytoskeletal organization, neuronal function, and related pathologies.

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spectrin α II Antibody (B-2) References:

1. Calpain proteolysis of alpha II-spectrin in the normal adult human brain.  |  Huh, GY., et al. 2001. Neurosci Lett. 316: 41-4. PMID: 11720774
2. Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain.  |  Nicolas, G., et al. 2002. Mol Cell Biol. 22: 3527-36. PMID: 11971983
3. Upregulation of dihydropyrimidinase-related protein 2, spectrin alpha II chain, heat shock cognate protein 70 pseudogene 1 and tropomodulin 2 after focal cerebral ischemia in rats--a proteomics approach.  |  Chen, A., et al. 2007. Neurochem Int. 50: 1078-86. PMID: 17196711
4. Prostaglandin-induced VASP phosphorylation controls alpha II-spectrin breakdown in apoptotic cells.  |  Benz, PM., et al. 2008. Int Immunopharmacol. 8: 319-24. PMID: 18182247
5. Characterization and expression of a heart-selective alternatively spliced variant of alpha II-spectrin, cardi+, during development in the rat.  |  Zhang, Y., et al. 2010. J Mol Cell Cardiol. 48: 1050-9. PMID: 20114050
6. Dominant-negative mutations in alpha-II spectrin cause West syndrome with severe cerebral hypomyelination, spastic quadriplegia, and developmental delay.  |  Saitsu, H., et al. 2010. Am J Hum Genet. 86: 881-91. PMID: 20493457
7. Cytoskeletal protein α-II spectrin degradation in the brain of repeated blast exposed mice.  |  Valiyaveettil, M., et al. 2014. Brain Res. 1549: 32-41. PMID: 24412202
8. Nonsense mutations in alpha-II spectrin in three families with juvenile onset hereditary motor neuropathy.  |  Beijer, D., et al. 2019. Brain. 142: 2605-2616. PMID: 31332438
9. An alpha II spectrin mutant peptide with unstable scaffold structure and increased sensitivity to calpain cleavage.  |  Skrzymowska, J., et al. 2021. Biochem Biophys Res Commun. 581: 68-73. PMID: 34656850
10. Progressive Ataxia, Memory Impairments, and Seizure Episodes in Spna2 R1098Q Mouse Variant Affecting Alpha II Spectrin's Scaffold Stability.  |  Zalas, M., et al. 2023. Brain Sci. 13: PMID: 36831804

The preferred spectrin α II antibody is spectrin α II Antibody (C-3): sc-48382.