SPARCL1 Antibody (D-1): sc-390199

SPARCL1 Antibody (D-1) is a mouse monoclonal IgG1 antibody that detects SPARCL1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SPARCL1, also known as high endothelial venule protein (Hevin) or MAST9, is a 664 amino acid glycoprotein that plays a crucial role in various biological processes, including neuronal remodeling and tumor suppression. SPARCL1 is primarily secreted by endothelial cells and is highly expressed in tissues such as lymph nodes, heart, lung, brain, skeletal muscle, ovary, colon, and small intestine, highlighting its importance in both normal physiology and disease states. Notably, SPARCL1 contains one EF-hand domain, one follistatin-like domain, and one Kazal-like domain, which contribute to functional versatility and interactions with other proteins. The presence of these domains suggests that SPARCL1 may engage in calcium-dependent signaling and protease inhibition, further underscoring its significance in cellular communication and tissue homeostasis. The gene encoding SPARCL1 is located on chromosome 4q22.1, and expression patterns and post-translational modifications are critical for understanding its role in health and disease.

The preferred SPARCL1 antibody is SPARCL1 Antibody (G-5): sc-514275.