SPARCL1 Antibody (G-5): sc-514275

SPARCL1 Antibody (G-5) is a mouse monoclonal IgM antibody that detects SPARCL1 of human, rat, and mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SPARCL1 antibody (G-5) is available as a non-conjugated format. SPARC-like protein 1 (SPARCL1), also known as high endothelial venule protein (Hevin) or MAST9, is a 664 amino acid member of the SPARC family of proteins, characterized by a unique structure including one EF-hand domain, one follistatin-like domain, and one Kazal-like domain. This intricate structure facilitates SPARCL1′s interactions with various extracellular matrix components and other proteins, influencing cellular processes such as adhesion, migration, and proliferation. SPARCL1 shows high expression in lymph nodes, heart, lung, brain, skeletal muscle, ovary, colon, and small intestine, playing a significant role in neuronal remodeling and tumor suppression, making SPARCL1 an important target for research in cancer biology and developmental processes. The gene encoding SPARCL1 is located on chromosome 4q22.1, highlighting genetic significance in various physiological and pathological contexts.

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SPARCL1 Antibody (G-5) References:

1. SPARC and Hevin expression correlate with tumour angiogenesis in hepatocellular carcinoma.  |  Lau, CP., et al. 2006. J Pathol. 210: 459-68. PMID: 17029219
2. Tumor-suppressor function of SPARC-like protein 1/Hevin in pancreatic cancer.  |  Esposito, I., et al. 2007. Neoplasia. 9: 8-17. PMID: 17325739
3. Analysis of the extracellular matrix protein SC1 during reactive gliosis in the rat lithium-pilocarpine seizure model.  |  Lively, S. and Brown, IR. 2007. Brain Res. 1163: 1-9. PMID: 17628511
4. Altered tissue repair in hevin-null mice: inhibition of fibroblast migration by a matricellular SPARC homolog.  |  Sullivan, MM., et al. 2008. Wound Repair Regen. 16: 310-9. PMID: 18318815
5. Localization of the extracellular matrix protein SC1 coincides with synaptogenesis during rat postnatal development.  |  Lively, S. and Brown, IR. 2008. Neurochem Res. 33: 1692-700. PMID: 18335312
6. A BAC transgenic mouse model to analyze the function of astroglial SPARCL1 (SC1) in the central nervous system.  |  Weimer, JM., et al. 2008. Glia. 56: 935-41. PMID: 18381651
7. The extracellular matrix protein SC1/hevin localizes to excitatory synapses following status epilepticus in the rat lithium-pilocarpine seizure model.  |  Lively, S. and Brown, IR. 2008. J Neurosci Res. 86: 2895-905. PMID: 18488994
8. Extracellular matrix protein SC1/hevin in the hippocampus following pilocarpine-induced status epilepticus.  |  Lively, S. and Brown, IR. 2008. J Neurochem. 107: 1335-46. PMID: 18808451

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SPARCL1 Antibody (G-5) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-SPARCL1 Antibody (G-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SPARCL1 Antibody (G-5) Specifications

Alternate Product Name: SPARCL1

Product Clone Name: G-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 586-600

Epitope Target: SPARCL1

Epitope Species: mouse

Product Reactivity/Detection: SPARCL1 of human and rat origin and Sc1 of mouse origin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for SPARCL1 Antibody (G-5): P: Blocking Peptide