SPA-1 Antibody (E-6): sc-166949
- SPA-1 Antibody (E-6) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 926-945 near the C-terminus of SPA-1 of human origin
- recommended for detection of SPA-1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SPA-1 Antibody (E-6) for WB applications. These reagents are now offered in bundles with SPA-1 Antibody (E-6) (see ordering information below).
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SPA-1 Antibody (E-6) is a mouse monoclonal IgG1 antibody that detects SPA-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SPA-1, or signal-induced proliferation-associated gene-1, serves as a crucial regulator in hematopoietic progenitors and peripheral T cells by acting as a principal GTPase-activating protein for RAP1. SPA-1′s ability to modulate RAP1 activity is vital for maintaining proper T cell function, as SPA-1 disrupts LFA-1-ICAM1-mediated adhesive interactions, which are essential for T cell receptor triggering and interleukin-2 production. Notably, SPA-1 is expressed in both fetal and adult lymphohematopoietic tissues, and SPA-1 expression is upregulated in response to various mitogenic stimuli, highlighting SPA-1′s role in immune responses. Mice lacking the SPA-1 gene exhibit age-dependent T cell immunodeficiency and develop myeloproliferative disorders that resemble human chronic myeloid leukemia, underscoring SPA-1′s importance in immune regulation and disease pathology. Additionally, SPA-1 interacts directly with aquaporin-2 (AQP2), influencing AQP2 trafficking to the apical membrane, which is critical for water homeostasis in renal function. Anti-SPA-1 antibody (E-6) is an essential tool for researchers investigating the complex roles of SPA-1 in immune responses and related disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SPA-1 Antibody (E-6) | sc-166949 | 200 µg/ml | $322.00 | |||
SPA-1 Antibody (E-6): m-IgG Fc BP-HRP Bundle | sc-537553 | 200 µg Ab; 10 µg BP | $361.00 | |||
SPA-1 Antibody (E-6): m-IgGκ BP-HRP Bundle | sc-534851 | 200 µg Ab; 40 µg BP | $361.00 | |||
SPA-1 Antibody (E-6): m-IgG1 BP-HRP Bundle | sc-545224 | 200 µg Ab; 20 µg BP | $361.00 | |||
SPA-1 (E-6) Neutralizing Peptide | sc-166949 P | 100 µg/0.5 ml | $69.00 |