Sp2 Antibody (G-7): sc-55487
- Sp2 Antibody (G-7) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 154-435 of Sp2 of human origin
- recommended for detection of Sp2 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Sp2 Antibody (G-7). This work is in progress.
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Sp2 Antibody (G-7) is a mouse monoclonal IgG1 antibody that detects Sp2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Sp2 is a member of the Sp transcription factor family, which also includes Sp1, Sp3, and Sp4, and is characterized by a highly conserved DNA-binding domain featuring three zinc fingers at its C-terminus. While Sp2 exhibits weak binding to GT boxes, Sp2 is distinct from Sp1, Sp3, and Sp4, which have a high affinity for GC boxes. Sp2 expression is primarily found in specific tissues, with its gene located on chromosome 17p32.3, and plays a crucial role in regulating gene expression. Notably, Sp2 interacts with various proteins, including E2, a regulatory element for the β4 subunit of neuronal nicotinic acetylcholine receptors, which highlights Sp2′s importance in neuronal signaling pathways. Anti-Sp2 antibody (G-7) is an essential tool for researchers studying the intricate roles of Sp2 in cellular processes and its implications in various biological contexts.
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Sp2 Antibody (G-7) References:
- Transcription Factor SP2 Enhanced the Expression of Cd14 in Colitis-Susceptible C3H/HeJBir. | Zschemisch, NH., et al. 2016. PLoS One. 11: e0155821. PMID: 27191968
- Transcription factor Sp2 potentiates binding of the TALE homeoproteins Pbx1:Prep1 and the histone-fold domain protein Nf-y to composite genomic sites. | Völkel, S., et al. 2018. J Biol Chem. 293: 19250-19262. PMID: 30337366
- SP2: Rapid and Automatable Contaminant Removal from Peptide Samples for Proteomic Analyses. | Waas, M., et al. 2019. J Proteome Res. 18: 1644-1656. PMID: 30795648
- Sargassum fusiforme Fucoidan SP2 Extends the Lifespan of Drosophila melanogaster by Upregulating the Nrf2-Mediated Antioxidant Signaling Pathway. | Zhang, Y., et al. 2019. Oxid Med Cell Longev. 2019: 8918914. PMID: 31485301
- Sp2 regulates late neurogenic but not early expansive divisions of neural stem cells underlying population growth in the mouse cortex. | Johnson, CA. and Ghashghaei, HT. 2020. Development. 147: PMID: 32001437
- Src-1 and SP2 promote the proliferation and epithelial-mesenchymal transition of nasopharyngeal carcinoma. | Zhang, J., et al. 2021. Open Med (Wars). 16: 1061-1069. PMID: 34307888
- Comparative systeomics to elucidate physiological differences between CHO and SP2/0 cell lines. | Demirhan, D., et al. 2022. Sci Rep. 12: 3280. PMID: 35228567
- Nickel-Catalyzed Csp2 -OMe Functionalization for Chemoselective Aromatic Homologation En Route to Nanographenes. | Capdevila, L., et al. 2022. Chemistry. 28: e202200625. PMID: 35322915
- Benchmarking of Two Peptide Clean-Up Protocols: SP2 and Ethyl Acetate Extraction for Sodium Dodecyl Sulfate or Polyethylene Glycol Removal from Plant Samples before LC-MS/MS. | Martinková, P., et al. 2023. Int J Mol Sci. 24: PMID: 38139176
- Copper-Catalyzed Intramolecular Decarboxylative C(sp2)-Heteroatom Cross-Couplings: Mechanism Insights and Synthetic Applications. | Pu, W., et al. 2024. J Org Chem. 89: 11939-11949. PMID: 39177441
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sp2 Antibody (G-7) | sc-55487 | 200 µg/ml | $322.00 |