Sox-18 Antibody (E-11): sc-376166
- Sox-18 Antibody (E-11) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 253-291 within an internal region of Sox-18 of human origin
- recommended for detection of Sox-18 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Sox-18 Antibody (E-11) for WB applications. These reagents are now offered in bundles with Sox-18 Antibody (E-11) (see ordering information below).
Sox-18 Antibody (E-11) is a mouse monoclonal IgG2a antibody that detects Sox-18 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Sox-18 is a crucial 384 amino acid nuclear protein that plays a significant role in the regulation of gene expression during development, particularly in the formation of blood vessels and hair follicles. Sox-18 contains one HMG box DNA-binding domain, which is essential for function as a transcriptional regulator, allowing binding to specific DNA sequences and influencing the transcription of target genes. Proper functioning of Sox-18 is vital for normal development, and mutations in this gene have been associated with various developmental disorders, including those affecting vascular and hair follicle formation. anti-Sox-18 antibody (E-11) provides a reliable tool for researchers studying the intricate roles of Sox-18 in developmental biology and implications in human diseases, enabling a deeper understanding of the molecular mechanisms underlying these processes.
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Sox-18 Antibody (E-11) References:
- SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function. | Fontijn, RD., et al. 2008. Am J Physiol Heart Circ Physiol. 294: H891-900. PMID: 18065521
- The lymphangiogenic factor SOX 18: a key indicator to stage gastric tumor progression. | Eom, BW., et al. 2012. Int J Cancer. 131: 41-8. PMID: 21796627
- Hydrops fetalis and pulmonary lymphangiectasia due to FOXC2 mutation: an autosomal dominant hereditary lymphedema syndrome with variable expression. | de Bruyn, G., et al. 2012. Eur J Pediatr. 171: 447-50. PMID: 21918810
- Effect of 17β-estradiol and flavonoids on the regulation of expression of newly identified oestrogen responsive genes in a rat raphe nuclei-derived cell line. | Amer, DA., et al. 2012. J Cell Physiol. 227: 3434-45. PMID: 22213181
- Role of nestin expression in angiogenesis and breast cancer progression. | Nowak, A., et al. 2018. Int J Oncol. 52: 527-535. PMID: 29345290
- The role of SOX family members in solid tumours and metastasis. | Grimm, D., et al. 2020. Semin Cancer Biol. 67: 122-153. PMID: 30914279
- Loss of SOX18/CLAUDIN5 disrupts the pulmonary endothelial barrier in ventilator-induced lung injury. | Garcia-Flores, AE., et al. 2022. Front Physiol. 13: 1066515. PMID: 36620216
- ERG Regulates Lymphatic Vessel Specification Genes and Its Deficiency Impairs Wound Healing-Associated Lymphangiogenesis. | Yamashita, T., et al. 2024. Arthritis Rheumatol. 76: 1645-1657. PMID: 38965683
- Trans-activation and DNA-binding properties of the transcription factor, Sox-18. | Hosking, BM., et al. 1995. Nucleic Acids Res. 23: 2626-8. PMID: 7651823
- Sequence and expression of Sox-18 encoding a new HMG-box transcription factor. | Dunn, TL., et al. 1995. Gene. 161: 223-5. PMID: 7665083
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sox-18 Antibody (E-11) | sc-376166 | 200 µg/ml | $316.00 | |||
Sox-18 Antibody (E-11): m-IgG Fc BP-HRP Bundle | sc-537976 | 200 µg Ab; 10 µg BP | $354.00 | |||
Sox-18 Antibody (E-11): m-IgGκ BP-HRP Bundle | sc-535472 | 200 µg Ab; 40 µg BP | $354.00 | |||
Sox-18 (E-11) Neutralizing Peptide | sc-376166 P | 100 µg/0.5 ml | $68.00 |