SorCS1 Antibody (E-8): sc-365605
- SorCS1 Antibody (E-8) is a mouse monoclonal IgG1 κ SorCS1 antibody provided at 200 µg/ml
- raised against amino acids 34-153 mapping near the N-terminus of SorCS1 of human origin
- SorCS1 Antibody (E-8) is recommended for detection of isoforms 1-4 of precursor and mature SorCS1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-SorCS1 Antibody (E-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SorCS1 Antibody (E-8) for WB applications. These reagents are now offered in bundles with SorCS1 Antibody (E-8) (see ordering information below).
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SorCS1 Antibody (E-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects SorCS1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SorCS1 (E-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. SorCS1 plays a crucial role in the central nervous system, where anti-SorCS1 antibody (E-8) detects protein involvement in sorting and trafficking of neurotrophic factors and receptors, essential for neuronal development and function. SorCS1 proper localization and function are vital for maintaining synaptic integrity and plasticity, fundamental for learning and memory processes. SorCS1 expression occurs in a combinatorial pattern alongside SorCS2 and SorCS3 homologs, highlighting importance in brain signaling pathways. Alternative splicing in human and murine SorCS1 results in multiple isoforms, each with distinct tissue distribution and functional implications, further underscoring complexity in neurobiology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SorCS1 Antibody (E-8) References:
- Identification and characterization of SorCS, a third member of a novel receptor family. | Hermey, G., et al. 1999. Biochem Biophys Res Commun. 266: 347-51. PMID: 10600506
- Transient expression of SorCS in developing telencephalic and mesencephalic structures of the mouse. | Hermey, G., et al. 2001. Neuroreport. 12: 29-32. PMID: 11201086
- The genes for the human VPS10 domain-containing receptors are large and contain many small exons. | Hampe, W., et al. 2001. Hum Genet. 108: 529-36. PMID: 11499680
- SorCS1, a member of the novel sorting receptor family, is localized in somata and dendrites of neurons throughout the murine brain. | Hermey, G., et al. 2001. Neurosci Lett. 313: 83-7. PMID: 11684345
- Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells. | Hermey, G., et al. 2003. J Biol Chem. 278: 7390-6. PMID: 12482870
- The three sorCS genes are differentially expressed and regulated by synaptic activity. | Hermey, G., et al. 2004. J Neurochem. 88: 1470-6. PMID: 15009648
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SorCS1 Antibody (E-8) | sc-365605 | 200 µg/ml | $322.00 | |||
SorCS1 Antibody (E-8): m-IgG Fc BP-HRP Bundle | sc-529405 | 200 µg Ab; 10 µg BP | $361.00 | |||
SorCS1 Antibody (E-8): m-IgGκ BP-HRP Bundle | sc-522288 | 200 µg Ab, 40 µg BP | $361.00 | |||
SorCS1 Antibody (E-8) AC | sc-365605 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SorCS1 Antibody (E-8) HRP | sc-365605 HRP | 200 µg/ml | $322.00 | |||
SorCS1 Antibody (E-8) FITC | sc-365605 FITC | 200 µg/ml | $336.00 | |||
SorCS1 Antibody (E-8) PE | sc-365605 PE | 200 µg/ml | $349.00 | |||
SorCS1 Antibody (E-8) Alexa Fluor® 488 | sc-365605 AF488 | 200 µg/ml | $364.00 | |||
SorCS1 Antibody (E-8) Alexa Fluor® 546 | sc-365605 AF546 | 200 µg/ml | $364.00 | |||
SorCS1 Antibody (E-8) Alexa Fluor® 594 | sc-365605 AF594 | 200 µg/ml | $364.00 | |||
SorCS1 Antibody (E-8) Alexa Fluor® 647 | sc-365605 AF647 | 200 µg/ml | $364.00 | |||
SorCS1 Antibody (E-8) Alexa Fluor® 680 | sc-365605 AF680 | 200 µg/ml | $364.00 | |||
SorCS1 Antibody (E-8) Alexa Fluor® 790 | sc-365605 AF790 | 200 µg/ml | $364.00 |