Soggy-1 Antibody (B-4): sc-393692

Soggy-1 Antibody (B-4) is a mouse monoclonal IgG2b antibody that detects Soggy-1 in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Soggy-1, a secreted antagonist of the Wnt signaling pathway, plays a crucial role in regulating developmental processes, particularly in preimplantation mouse embryos and developing neural tissue, as well as in adult testis tissue. Soggy-1 (B-4) antibody enables researchers to study how this protein modulates Wnt activity, ensuring proper spatial and temporal expression of Wnt target genes, which is vital for normal embryogenesis and tissue patterning. Anti-Soggy-1 antibody (B-4) helps detect interactions with Wnt proteins and their receptors, thereby revealing downstream signaling cascades that govern cell fate decisions. Soggy-1 undergoes post-translational modifications, including glycosylation, which can affect stability and activity, although additional modifications remain to be fully characterized. The molecular weight of Soggy-1 can vary depending on the tissue and cell type, highlighting the complexity of regulation and function in various biological contexts. Anti-Soggy-1 antibody (B-4) serves as an essential tool for researchers investigating the intricate roles of Wnt signaling in development and disease.

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Soggy-1 Antibody (B-4) References:

1. DkkL1 (Soggy), a Dickkopf family member, localizes to the acrosome during mammalian spermatogenesis.  |  Kohn, MJ., et al. 2005. Mol Reprod Dev. 71: 516-22. PMID: 15892050
2. Function and biological roles of the Dickkopf family of Wnt modulators.  |  Niehrs, C. 2006. Oncogene. 25: 7469-81. PMID: 17143291
3. Transcriptome analysis identifies pathways associated with enhanced maternal performance in QSi5 mice.  |  Ramanathan, P., et al. 2008. BMC Genomics. 9: 197. PMID: 18442417
4. Dickkopf-like1 regulates postpubertal spermatocyte apoptosis and testosterone production.  |  Dakhova, O., et al. 2009. Endocrinology. 150: 404-12. PMID: 18818293
5. Effects of FSH on testicular mRNA transcript levels in the hypogonadal mouse.  |  Abel, MH., et al. 2009. J Mol Endocrinol. 42: 291-303. PMID: 19136570
6. The acrosomal protein Dickkopf-like 1 (DKKL1) is not essential for fertility.  |  Kaneko, KJ., et al. 2010. Fertil Steril. 93: 1526-32. PMID: 19596310
7. The acrosomal protein Dickkopf-like 1 (DKKL1) facilitates sperm penetration of the zona pellucida.  |  Kohn, MJ., et al. 2010. Fertil Steril. 93: 1533-7. PMID: 19596312
8. SLXL1, a novel acrosomal protein, interacts with DKKL1 and is involved in fertilization in mice.  |  Zhuang, XJ., et al. 2011. PLoS One. 6: e20866. PMID: 21698294
9. Developmental expression and function of DKKL1/Dkkl1 in humans and mice.  |  Yan, Q., et al. 2012. Reprod Biol Endocrinol. 10: 51. PMID: 22817830
10. Region-specific expression of Dickkopf-like1 in the adult brain. Abbreviated title: Dkkl1 in the adult brain.  |  Sibbe, M. and Jarowyj, J. 2013. Neurosci Lett. 535: 84-9. PMID: 23295900

The preferred Soggy-1 antibody is Soggy-1 Antibody (E-12): sc-271563.