SNX27 Antibody (1C6): sc-130564

SNX27 Antibody (1C6) is a mouse monoclonal IgG1 antibody that detects SNX27 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SNX27 is a crucial protein that plays a significant role in intracellular trafficking and recycling pathways, primarily localized in the cytoplasm and early endosome. SNX27 structure includes a characteristic phox homology (PX) domain, a Ras-associating domain, and a PDZ domain, which are essential for vesicular localization and function. The PDZ domain, in particular, is vital for protein-protein interactions, allowing SNX27 to recruit other proteins such as CYTIP and SR-4, thereby facilitating the endocytic trafficking of various receptors. The presence of four named isoforms of SNX27, resulting from alternative splicing events, highlights the complexity and regulatory potential in cellular processes. SNX27 (1C6) antibody enables researchers to gain insights into the dynamics of endosomal trafficking and the functional implications of SNX27 in various biological contexts.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SNX27 Antibody (1C6) References:

1. SNX27-Mediated Recycling of Neuroligin-2 Regulates Inhibitory Signaling.  |  Halff, EF., et al. 2019. Cell Rep. 29: 2599-2607.e6. PMID: 31775031
2. Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS.  |  González-Mancha, N. and Mérida, I. 2020. Int J Mol Sci. 21: PMID: 32549284
3. Toward Understanding the Molecular Role of SNX27/Retromer in Human Health and Disease.  |  Chandra, M., et al. 2021. Front Cell Dev Biol. 9: 642378. PMID: 33937239
4. Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation.  |  Del Puerto, A., et al. 2021. Mol Psychiatry. 26: 6411-6426. PMID: 34002021
5. Biochemical basis for an interaction between SNX27 and the flexible SNX1 N-terminus.  |  Chandra, M., et al. 2022. Adv Biol Regul. 83: 100842. PMID: 34866035
6. SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry.  |  Yang, B., et al. 2022. Proc Natl Acad Sci U S A. 119: PMID: 35022217
7. Circ_SNX27 regulates hepatocellular carcinoma development via miR-637/FGFR1 axis.  |  Li, H., et al. 2022. Environ Toxicol. 37: 2832-2843. PMID: 36029209
8. Endosomal Sorting Protein SNX27 and Its Emerging Roles in Human Cancers.  |  Deb, S. and Sun, J. 2022. Cancers (Basel). 15: PMID: 36612066
9. Circ-SNX27 sponging miR-375/RPN1 axis contributes to hepatocellular carcinoma progression.  |  Zheng, C., et al. 2023. Korean J Physiol Pharmacol. 27: 333-344. PMID: 37386831
10. SNX27: A trans-species cognitive modulator with implications for anxiety and stress susceptibility.  |  Armada, G., et al. 2024. Neurobiol Stress. 30: 100619. PMID: 38500791

The preferred SNX27 antibody is SNX27 Antibody (F-2): sc-515707.