SNAP 25 Antibody (4E203): sc-73044
- SNAP 25 Antibody (4E203) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against synaptic vesicle-containing fractions immunoprecipitated from human brain homogenates using anti-human synaptophysin monoclonal antibodies
- recommended for detection of SNAP 25 of mouse, rat and human origin by WB and IP; may cross-react with higher molecular weight proteins in some tissue extracts; non cross-reactive with ~27 kDa proteins in mouse liver extracts
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SNAP 25 Antibody (4E203) for WB applications. These reagents are now offered in bundles with SNAP 25 Antibody (4E203) (see ordering information below).
SNAP 25 Antibody (4E203) is a mouse monoclonal IgG1 antibody that detects SNAP 25 in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. SNAP 25 is a critical component of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex, which plays a vital role in neurotransmitter release at synapses. SNAP 25 is primarily located in the presynaptic membrane of neurons, where SNAP 25 facilitates the fusion of synaptic vesicles with the plasma membrane, allowing for efficient release of neurotransmitters into the synaptic cleft. Proper functioning of SNAP 25 is essential for synaptic transmission and communication between neurons, making SNAP 25 a key player in various neurological processes. Dysregulation of SNAP 25 has been implicated in several neurological disorders, including schizophrenia and autism spectrum disorders, highlighting SNAP 25′s importance in maintaining synaptic health and function. Anti-SNAP 25 antibody (4E203) serves as an invaluable tool for researchers studying synaptic mechanisms and the molecular underpinnings of neurodegenerative diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SNAP 25 Antibody (4E203) References:
- SNAP-23 and SNAP-25 are palmitoylated in vivo. | Vogel, K. and Roche, PA. 1999. Biochem Biophys Res Commun. 258: 407-10. PMID: 10329400
- Expression of SNAP-25 during mammalian retinal development: thinking outside the synapse. | Greenlee, MH., et al. 2002. Semin Cell Dev Biol. 13: 99-106. PMID: 12127142
- Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis. | Fossati, G., et al. 2015. Cell Death Differ. 22: 1425-36. PMID: 25678324
- Quantitative mass spectrometry reveals changes in SNAP-25 isoforms in schizophrenia. | Barakauskas, VE., et al. 2016. Schizophr Res. 177: 44-51. PMID: 26971072
- Presynaptic SNAP-25 regulates retinal waves and retinogeniculate projection via phosphorylation. | Hsiao, YT., et al. 2019. Proc Natl Acad Sci U S A. 116: 3262-3267. PMID: 30728295
- Sarcopenia associates with SNAP-25 SNPs and a miRNAs profile which is modulated by structured rehabilitation treatment. | Agostini, S., et al. 2021. J Transl Med. 19: 315. PMID: 34289870
- Quantification of SNAP-25 with mass spectrometry and Simoa: a method comparison in Alzheimer's disease. | Nilsson, J., et al. 2022. Alzheimers Res Ther. 14: 78. PMID: 35659284
- Distinct exocytotic responses of intact and permeabilised chromaffin cells after cleavage of the 25-kDa synaptosomal-associated protein (SNAP-25) or synaptobrevin by botulinum toxin A or B. | Lawrence, GW., et al. 1996. Eur J Biochem. 236: 877-86. PMID: 8665909
- Targeting of SNAP-23 and SNAP-25 in polarized epithelial cells. | Low, SH., et al. 1998. J Biol Chem. 273: 3422-30. PMID: 9452464
- Differential expression of SNAP-25 isoforms and SNAP-23 in the adrenal gland. | Grant, NJ., et al. 1999. J Neurochem. 72: 363-72. PMID: 9886089
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SNAP 25 Antibody (4E203) | sc-73044 | 200 µg/ml | $316.00 | |||
SNAP 25 Antibody (4E203): m-IgG Fc BP-HRP Bundle | sc-537214 | 200 µg Ab; 10 µg BP | $354.00 | |||
SNAP 25 Antibody (4E203): m-IgGκ BP-HRP Bundle | sc-534425 | 200 µg Ab; 40 µg BP | $354.00 | |||
SNAP 25 Antibody (4E203): m-IgG1 BP-HRP Bundle | sc-545084 | 200 µg Ab; 20 µg BP | $354.00 |