SNAP 23 Antibody (F-1): sc-373743

SNAP 23 Antibody (F-1) is a mouse monoclonal IgG1 antibody that detects SNAP 23 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SNAP 23 is a critical protein involved in the regulation of vesicle docking and fusion, which is essential for processes such as neurotransmitter release and hormone secretion. SNAP 23 is primarily located in the cytoplasm and is associated with the plasma membrane, where SNAP 23 plays a pivotal role in exocytosis by forming a stable complex with v-SNAREs and t-SNAREs. The interaction of SNAP 23 with these proteins facilitates the fusion of vesicles with target membranes, ensuring the proper delivery of cargo within the cell. SNAP 23 is expressed in all mammalian cells, highlighting SNAP 23′s fundamental role in cellular communication and transport mechanisms. The human SNAP 23 gene encodes two isoforms, SNAP 23A and SNAP 23B, with SNAP 23B being a truncated version of SNAP 23A, lacking specific amino acid residues that may influence functional properties. The versatility of anti-SNAP 23 antibody (F-1) in various applications makes SNAP 23 an invaluable tool for researchers studying cellular transport mechanisms and the underlying processes of exocytosis.

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SNAP 23 Antibody (F-1) References:

1. Function of the t-SNARE SNAP-23 and secretory carrier membrane proteins (SCAMPs) in exocytosis in mast cells.  |  Castle, JD., et al. 2002. Mol Immunol. 38: 1337-40. PMID: 12217404
2. Heterogeneous expression of SNARE proteins SNAP-23, SNAP-25, Syntaxin1 and VAMP in human parathyroid tissue.  |  Lu, M., et al. 2008. Mol Cell Endocrinol. 287: 72-80. PMID: 18457912
3. Deletion of SNAP-23 results in pre-implantation embryonic lethality in mice.  |  Suh, YH., et al. 2011. PLoS One. 6: e18444. PMID: 21479242
4. The cysteine-rich domain of synaptosomal-associated protein of 23 kDa (SNAP-23) regulates its membrane association and regulated exocytosis from mast cells.  |  Agarwal, V., et al. 2019. Biochim Biophys Acta Mol Cell Res. 1866: 1618-1633. PMID: 31260699
5. Depletion of SNAP-23 and Syntaxin 4 alters lipid droplet homeostasis during Chlamydia infection.  |  Monteiro-Brás, T., et al. 2019. Microb Cell. 7: 46-58. PMID: 32025513
6. Reduced O-GlcNAcylation of SNAP-23 promotes cisplatin resistance by inducing exosome secretion in ovarian cancer.  |  Qian, L., et al. 2021. Cell Death Discov. 7: 112. PMID: 34001861
7. Ability of human SNAP-23 to generate high molecular weight SDS-resistant ternary SNARE complexes is influenced by C-terminal coil content.  |  Vaidyanathan, VV. and Binz, T. 2021. Biochem Biophys Rep. 28: 101150. PMID: 34703905
8. Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c.  |  Araki, S., et al. 1997. Biochem Biophys Res Commun. 234: 257-62. PMID: 9168999
9. SNAP-23 in rat kidney: colocalization with aquaporin-2 in collecting duct vesicles.  |  Inoue, T., et al. 1998. Am J Physiol. 275: F752-60. PMID: 9815132
10. Differential expression of SNAP-25 isoforms and SNAP-23 in the adrenal gland.  |  Grant, NJ., et al. 1999. J Neurochem. 72: 363-72. PMID: 9886089

The preferred SNAP 23 antibody is SNAP 23 Antibody (D-11): sc-374215.