SNAP 23 Antibody (E-5): sc-374060
- SNAP 23 Antibody (E-5) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 86-135 mapping within an internal region of SNAP 23 of human origin
- recommended for detection of SNAP 23A of human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for SNAP 23 Antibody (E-5) for WB applications. This reagent is now offered in a bundle with SNAP 23 Antibody (E-5) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
SNAP 23 Antibody (E-5) is a mouse monoclonal IgG1 antibody that detects SNAP 23 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SNAP 23 is a critical protein involved in the regulation of vesicle docking and fusion, which is essential for processes such as neurotransmitter release and hormone secretion. Located in the cytoplasm and associated with the plasma membrane, SNAP 23 plays a pivotal role in exocytosis by forming a stable complex with v-SNAREs and t-SNAREs, facilitating the fusion of vesicles with target membranes. This process is vital for maintaining cellular communication and homeostasis, as SNAP 23 allows for the precise delivery of proteins and other molecules to their intended locations within the cell. The human SNAP 23 gene encodes two isoforms, SNAP 23A and SNAP 23B, with SNAP 23B being a truncated version of SNAP 23A. The ubiquitous expression of SNAP 23 across all mammalian cells underscores its importance in various physiological functions, making anti-SNAP 23 antibody (E-5) an invaluable tool for researchers studying cellular transport mechanisms and their implications in health and disease.
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SNAP 23 Antibody (E-5) References:
- Organization of the secretory machinery in the rodent brain: distribution of the t-SNAREs, SNAP-25 and SNAP-23. | Chen, D., et al. 1999. Brain Res. 831: 11-24. PMID: 10411979
- Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis. | Martín-Martín, B., et al. 2000. Blood. 96: 2574-83. PMID: 11001914
- Phosphorylation of SNAP-23 in activated human platelets. | Polgár, J., et al. 2003. J Biol Chem. 278: 44369-76. PMID: 12930825
- The SNARE proteins SNAP-25 and SNAP-23 display different affinities for lipid rafts in PC12 cells. Regulation by distinct cysteine-rich domains. | Salaün, C., et al. 2005. J Biol Chem. 280: 1236-40. PMID: 15542596
- SNAP-23 is not essential for constitutive exocytosis in HeLa cells. | Okayama, M., et al. 2007. FEBS Lett. 581: 4583-8. PMID: 17825825
- A neuronal role for SNAP-23 in postsynaptic glutamate receptor trafficking. | Suh, YH., et al. 2010. Nat Neurosci. 13: 338-43. PMID: 20118925
- TAT-SNAP-23 treatment inhibits the priming of neutrophil functions contributing to shock and/or sepsis-induced extra-pulmonary acute lung injury. | Bai, J., et al. 2015. Innate Immun. 21: 42-54. PMID: 24391146
- Phosphorylation of SNAP-23 at Ser95 causes a structural alteration and negatively regulates Fc receptor-mediated phagosome formation and maturation in macrophages. | Sakurai, C., et al. 2018. Mol Biol Cell. 29: 1753-1762. PMID: 29771640
- Methiothepin downregulates SNAP-23 and inhibits degranulation of rat basophilic leukemia cells and mouse bone marrow-derived mast cells. | Kondo, D., et al. 2023. Eur J Immunol. 53: e2250360. PMID: 37736882
- Tissue distribution of SNAP-23 and its subcellular localization in 3T3-L1 cells. | Wong, PP., et al. 1997. Biochem Biophys Res Commun. 230: 64-8. PMID: 9020061
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SNAP 23 Antibody (E-5) | sc-374060 | 200 µg/ml | $316.00 | |||
SNAP 23 Antibody (E-5): m-IgGκ BP-HRP Bundle | sc-522603 | 200 µg Ab, 40 µg BP | $354.00 |