SMOC-1 Antibody (C-2): sc-133235

SMOC-1 Antibody (C-2) is a mouse monoclonal IgG1 antibody that detects SMOC-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SMOC-1, or SPARC-related modular calcium-binding protein-1, plays a crucial role in the extracellular matrix, particularly in the basement membrane, where SMOC-1 is involved in tissue remodeling, angiogenesis, and bone mineralization. SMOC-1′s structure is characterized by the presence of two EF-hand domains, one Kazal-like domain, and two thyroglobulin type-1 domains, which are essential for calcium-binding capabilities and interactions with other proteins. These structural features enable SMOC-1 to participate in various biological processes, including the regulation of cell adhesion and migration, which are vital for normal development and wound healing. Expression of SMOC-1 during critical stages of embryogenesis, particularly in the basement membrane zones of multiple organs such as the brain, blood vessels, skin, and heart, underscores SMOC-1′s multifunctional roles in organ development and homeostasis. With broad species reactivity and versatile applications, anti-SMOC-1 antibody (C-2) serves as an invaluable tool for researchers studying this protein′s intricate roles in health and disease.

The preferred SMOC-1 antibody is SMOC-1 Antibody (A-10): sc-390448.