SMOC-1 Antibody (A-10): sc-390448

SMOC-1 Antibody (A-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects SMOC-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SMOC-1 (A-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SMOC-1, also known as SPARC-related modular calcium-binding protein-1, plays a crucial role in the extracellular matrix, particularly in the basement membrane, where SMOC-1 is involved in tissue remodeling, angiogenesis, and bone mineralization. Notably, SMOC-1 contains two EF-hand domains, a Kazal-like domain, and two thyroglobulin type-1 domains, which contribute to structural integrity and functional versatility. SMOC-1 presence in the basement membrane zones of various organs during embryonic development, including brain, blood vessels, skin, skeletal muscle, lung, heart, liver, pancreas, ovary, intestine, and kidney, underscores SMOC-1′s importance in organogenesis and suggests multiple functional roles throughout development. SMOC-1′s ability to interact with specific proteins in the extracellular matrix further highlights SMOC-1′s significance in cellular signaling and tissue homeostasis, making anti-SMOC-1 antibody (A-10) an essential tool for researchers studying developmental biology and related fields.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SMOC-1 Antibody (A-10) References:

1. Characterization of SMOC-1, a novel modular calcium-binding protein in basement membranes.  |  Vannahme, C., et al. 2002. J Biol Chem. 277: 37977-86. PMID: 12130637
2. Characterization of SMOC-2, a modular extracellular calcium-binding protein.  |  Vannahme, C., et al. 2003. Biochem J. 373: 805-14. PMID: 12741954
3. Transcriptional status of known and novel genes tagged with consensus of 33.15 repeat loci employing minisatellite-associated sequence amplification (MASA) and real-time PCR in water buffalo, Bubalus bubalis.  |  Srivastava, J., et al. 2006. DNA Cell Biol. 25: 31-48. PMID: 16405399
4. Secreted modular calcium-binding protein-1 localization during mouse embryogenesis.  |  Gersdorff, N., et al. 2006. Histochem Cell Biol. 126: 705-12. PMID: 16736127
5. A whole genome scan for pulse pressure/stroke volume ratio in African Americans: the HyperGEN study.  |  Sherva, R., et al. 2007. Am J Hypertens. 20: 398-402. PMID: 17386346
6. Characterization of Smoc-1 uncovers two transcript variants showing differential tissue and age specific expression in Bubalus bubalis.  |  Srivastava, J., et al. 2007. BMC Genomics. 8: 436. PMID: 18042303

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SMOC-1 Antibody (A-10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SMOC-1 Antibody (A-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SMOC-1 Antibody (A-10) Specifications

Alternate Product Name: SMOC-1

Product Clone Name: A-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 300-314

Epitope Target: SMOC-1

Epitope Species: human

Product Reactivity/Detection: SMOC-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SMOC-1 Antibody (A-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin