Anti-SMN Antibody (2B1) is a mouse monoclonal IgG1 κ SMN antibody, cited in 17 publications, provided at 200 µg/ml
raised against purified human recombinant His6 tagged-SMN protein
SMN Antibody (2B1) is recommended for detection of SMN of mouse, rat, human and Xenopus origin by WB, IP, IF and IHC(P)
Anti-SMN Antibody (2B1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of SMN (2B1): sc-32313.
m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SMN Antibody (2B1) for WB and IHC(P) applications. These reagents are now offered in bundles with SMN Antibody (2B1) (see ordering information below).
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
SMN Antibody (2B1) is a high quality monoclonal SMN antibody (also designated Gemin 1 antibody or Survival motor neuron protein antibody) suitable for the detection of the SMN protein of mouse, rat, human and Xenopus laevis origin. SMN Antibody (2B1) is available as both the non-conjugated anti-SMN antibody form, as well as multiple conjugated forms of anti-SMN antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by loss of motor neurons in the spinal cord. SMA is caused by deletion or loss-of-function mutations of SMN (survival of motor neuron) gene. SMN, also known as Gemin1, SMN1, SMNT and BCD541, exists as four isoforms produced by alternative splicing. SMN is oligomeric and forms a complex with Gemin2 (formerly SIP1), Gemin3 (a DEAD box RNA helicase), Gemin4, Gemin5 and Gemin6, as well as several spliceosomal snRNP proteins. The SMN complex plays an essential role in splicesomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing of the nucleus. The SMN complex is found in both the cytoplasm and the nucleus. The nuclear form is concentrated in subnuclear bodies called gems (gemini of the coiled bodies). Cytoplasmic SMN interacts with spliceosomal Sm proteins and facilitates their assembly onto U snRNAs, and nuclear SMN mediates recycling of pre-mRNA splicing factors. Nearly identical telomeric and centromeric forms of SMN encode the same protein; however, only mutations in the telomeric form are associated with the disease-state SMA. SMN is expresed in a wide variety of tissues including brain, kidney, liver, spinal cord and moderately in skeletal and cardiac muscle.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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