SMCR7 Antibody (A-5): sc-515759
- SMCR7 Antibody (A-5) is a mouse monoclonal IgG2b κ SMCR7 antibody provided at 200 µg/ml
- raised against amino acids 85-244 mapping within an internal region of SMCR7 of mouse origin
- SMCR7 Antibody (A-5) is recommended for detection of SMCR7 of mouse and rat origin by WB, IP, IF and ELISA
- Anti-SMCR7 Antibody (A-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SMCR7 Antibody (A-5) for WB applications. These reagents are now offered in bundles with SMCR7 Antibody (A-5) (see ordering information below).
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SMCR7 Antibody (A-5) is a mouse monoclonal IgG2b kappa light chain antibody that detects SMCR7 of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SMCR7 (A-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SMCR7, also known as Smith-Magenis syndrome chromosomal region candidate gene 7, is a 454 amino acid single-pass membrane protein that plays a crucial role in cellular signaling and membrane dynamics. SMCR7 expression is notably highest in skeletal muscle and heart tissues, which is significant as these tissues are vital for movement and circulation. SMCR7 localization in the cell membrane is essential for function, as SMCR7 facilitates interactions with other membrane proteins and receptors, thereby influencing various physiological processes. Mutations or deletions in the gene encoding SMCR7 are associated with Smith-Magenis syndrome, a disorder characterized by multiple congenital anomalies, mental retardation, and behavioral issues, highlighting SMCR7′s relevance in developmental biology and genetics. Understanding SMCR7 function and interactions can provide insights into the underlying mechanisms of this syndrome and aid in the development of targeted therapies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SMCR7 Antibody (A-5) References:
- Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. | Bi, W., et al. 2002. Genome Res. 12: 713-28. PMID: 11997338
- Neurologic and developmental features of the Smith-Magenis syndrome (del 17p11.2). | Gropman, AL., et al. 2006. Pediatr Neurol. 34: 337-50. PMID: 16647992
- New developments in Smith-Magenis syndrome (del 17p11.2). | Gropman, AL., et al. 2007. Curr Opin Neurol. 20: 125-34. PMID: 17351481
- Smith-Magenis syndrome. | Elsea, SH. and Girirajan, S. 2008. Eur J Hum Genet. 16: 412-21. PMID: 18231123
- Smith-Magenis syndrome: a new contiguous gene syndrome. Report of three new cases. | Moncla, A., et al. 1991. J Med Genet. 28: 627-32. PMID: 1956064
- Autism spectrum features in Smith-Magenis syndrome. | Laje, G., et al. 2010. Am J Med Genet C Semin Med Genet. 154C: 456-62. PMID: 20981775
- Constitutional interstitial deletion of 17(p11.2) (Smith-Magenis syndrome): a clinically recognizable microdeletion syndrome. Report of two cases and review of the literature. | Fischer, H., et al. 1993. Klin Padiatr. 205: 162-6. PMID: 8350589
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SMCR7 Antibody (A-5) | sc-515759 | 200 µg/ml | $322.00 | |||
SMCR7 Antibody (A-5): m-IgG Fc BP-HRP Bundle | sc-531502 | 200 µg Ab; 10 µg BP | $361.00 | |||
SMCR7 Antibody (A-5): m-IgGκ BP-HRP Bundle | sc-525202 | 200 µg Ab, 40 µg BP | $361.00 | |||
SMCR7 Antibody (A-5) AC | sc-515759 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SMCR7 Antibody (A-5) HRP | sc-515759 HRP | 200 µg/ml | $322.00 | |||
SMCR7 Antibody (A-5) FITC | sc-515759 FITC | 200 µg/ml | $336.00 | |||
SMCR7 Antibody (A-5) PE | sc-515759 PE | 200 µg/ml | $349.00 | |||
SMCR7 Antibody (A-5) Alexa Fluor® 488 | sc-515759 AF488 | 200 µg/ml | $364.00 | |||
SMCR7 Antibody (A-5) Alexa Fluor® 546 | sc-515759 AF546 | 200 µg/ml | $364.00 | |||
SMCR7 Antibody (A-5) Alexa Fluor® 594 | sc-515759 AF594 | 200 µg/ml | $364.00 | |||
SMCR7 Antibody (A-5) Alexa Fluor® 647 | sc-515759 AF647 | 200 µg/ml | $364.00 | |||
SMCR7 Antibody (A-5) Alexa Fluor® 680 | sc-515759 AF680 | 200 µg/ml | $364.00 | |||
SMCR7 Antibody (A-5) Alexa Fluor® 790 | sc-515759 AF790 | 200 µg/ml | $364.00 |