SIGIRR Antibody (G-8): sc-515818

SIGIRR Antibody (G-8) is a mouse monoclonal IgG1 antibody that detects SIGIRR in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SIGIRR, also known as single immunoglobulin domain-containing IL-1 receptor-related protein or Toll/interleukin-1 receptor 8 (TIR8), plays a crucial role as a negative regulator of the interleukin-1 receptor and Toll-like receptor signaling pathways, which are vital for the immune response. By modulating these pathways, SIGIRR helps to prevent excessive inflammation and tissue damage, thereby conferring resistance to infections, such as those caused by Pseudomonas aeruginosa in corneal tissues. SIGIRR is primarily localized in the kidney, lung, and gut, where SIGIRR expression is essential for maintaining immune homeostasis and protecting against pathogenic challenges. Additionally, SIGIRR can form complexes with key signaling molecules, including IL-1 receptor 1, MYD-88, IRAK-1, and TRAF-6, upon stimulation, highlighting SIGIRR′s integral role in the immune signaling cascade. With SIGIRR′s ability to interact with these proteins, SIGIRR serves as a critical checkpoint in the immune response, making SIGIRR a valuable target for research in inflammation and immune regulation.

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SIGIRR Antibody (G-8) References:

1. SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms.  |  Qin, J., et al. 2005. J Biol Chem. 280: 25233-41. PMID: 15866876
2. Lack of SIGIRR/TIR8 aggravates hydrocarbon oil-induced lupus nephritis.  |  Lech, M., et al. 2010. J Pathol. 220: 596-607. PMID: 20112371
3. SIGIRR modulates the inflammatory response in the brain.  |  Watson, MB., et al. 2010. Brain Behav Immun. 24: 985-95. PMID: 20394816
4. Down-regulation of single immunoglobulin interleukin-1R-related molecule (SIGIRR)/TIR8 expression in intestinal epithelial cells during inflammation.  |  Kadota, C., et al. 2010. Clin Exp Immunol. 162: 348-61. PMID: 21077278
5. SIGIRR genetic variants in premature infants with necrotizing enterocolitis.  |  Sampath, V., et al. 2015. Pediatrics. 135: e1530-4. PMID: 25963006
6. The anti-inflammatory IL-37/SIGIRR axis is functionally compromised in HIV infection.  |  Samarani, S., et al. 2019. AIDS. 33: 1693-1703. PMID: 31149943
7. Resveratrol prevents liver damage in MCD-induced steatohepatitis mice by promoting SIGIRR gene transcription.  |  Che, Y., et al. 2020. J Nutr Biochem. 82: 108400. PMID: 32438122
8. MiR-340 suppresses CCl4-induced acute liver injury through exerting anti-inflammation targeting Sigirr.  |  Liu, HH. and Li, AJ. 2020. Eur Rev Med Pharmacol Sci. 24: 10687-10695. PMID: 33155227
9. Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction.  |  Wang, Z., et al. 2022. Signal Transduct Target Ther. 7: 19. PMID: 35046386
10. Interleukin-37 promotes DMBA/TPA skin cancer through SIGIRR-mediated inhibition of glycolysis in CD103+DC cells.  |  Zeng, FL., et al. 2023. MedComm (2020). 4: e229. PMID: 36891351

The preferred SIGIRR antibody is SIGIRR Antibody (A-4): sc-271864.